Dr. Lincoln Stein - Ontario Institute for Cancer Research

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Dr. Lincoln Stein

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Dr. Lincoln Stein

Head, Adaptive Oncology

lincoln.stein@oicr.on.ca

Michelle Xin
Executive Assistant, Adaptive Oncology
Michelle.Xin@oicr.on.ca

Head, Adaptive Oncology

Dr. Lincoln Stein focuses on supporting biomedical research both in Ontario and around the world by making large and complex biological datasets findable, accessible and usable.

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Prior to joining OICR in 2006, Dr. Stein played an integral role in many large-scale data initiatives at Cold Spring Harbor Laboratory and at the Massachusetts Institute of Technology (MIT) Genome Center. He led the development of the first physical clone map of the human genome, and ran the data coordinating centre and the data portal for the SNP Consortium and the HapMap Consortium. Dr. Stein has also led the creation and development of Wormbase, a community model organism database for C. elegans, and Reactome, which is now the largest open community database of biological reactions and pathways.

At OICR, Dr. Stein has led several international cancer data sharing and research initiatives, including the creation and development of the data coordination centre for the International Cancer Genome Consortium and other related projects. He continues to collaborate with national and international partners to create and promote data sharing standards, protocols and implementations.

Experience & Education

Interim Scientific Director, OICR
Program Director, Informatics and Bio-computing, OICR
Professor, Cold Spring Harbor, New York
Associate Professor, Cold Spring Harbor, New York
Director Information Systems, CuraGen Corporation
Instructor, Harvard Medical School, Deptartment of Pathology, Brigham and Women’s Hospital
Director, Informatics Core, MIT Genome Center, Whitehead Institute for Biomedical Research, MIT
Residency, Anatomic Pathology, Brigham and Women’s Hospital
MD, Harvard Medical School
PhD, Cell Biology, Harvard University

Current Affiliations

Head, Adaptive Oncology, OICR
Chair of the International Cancer Genome Consortium Executive Committee, International Scientific Steering Committee and Data Coordination and Management Committee
Member of the Pan Cancer Analysis of Whole Genomes (PCAWG) Steering Committee
Member of the ICGCmed Scientific Planning Committee Data Coordination and Management Committee
Professor, Department of Molecular Genomics, University of Toronto

Select Publications

Shuai S, Suzuki H, Diaz-navarro A, …, Stein LD. The U1 spliceosomal RNA is recurrently mutated in multiple cancers. Nature. 2019;574(7780):712-716.
Vladoiu MC, El-hamamy I, Donovan LK, …, Stein L, Taylor MD. Childhood cerebellar tumours mirror conserved fetal transcriptional programs. Nature. 2019;572(7767):67-73.
Shlush LI, Zandi S, Mitchell A, …, Stein LD, …, Dick JE. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature. 2014;506(7488):328-33.
Gonzalez-Perez A, Mustonen V, Reva B, …, Stein LD, Lopez-Bigas N; International Cancer Genome Consortium Mutation Pathways and Consequences Subgroup of the Bioinformatics Analyses Working Group. Computational approaches to identify functional genetic variants in cancer genomes. Nat Methods. 2013;10(8):723-9.
Trinh QM, Jen FY, Zhou Z, …, Stein LD. Cloud-based uniform ChIP-Seq processing tools for modENCODE and ENCODE. BMC Genomics. 2013;14:494.

See Dr. Stein’s recent publications on PubMed or on Google Scholar.

Research Areas

Biology Cancer Origins Early Detection and Diagnosis Informatics and Data Standards

Disease Areas

All

Awards

Dr. Stein was named one of the World’s Most Influential Scientific Minds by Thompson Reuters in 2014 and a Fellow of the International Society of Computational Biology (ISCB) in 2016. He was recently awarded the Canadian Cancer Research Alliance’s Outstanding Achievements in Cancer Research Award (2019).

Opportunities to Collaborate

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Programs

Adaptive Oncology

The goal of the Adaptive Oncology Initiative is to develop “adaptive” approaches to cancer management that anticipate how tumours change over the course of time and in response to therapy.

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Tools

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