Lakshmi Muthuswamy

Overview

Dr. Muthuswamy's lab will be investigating the role of copy number variations (CNVs) in human diseases. CNVs can arise either somatically or in the germline. The somatic mutations, often seen in cancer, may provide an insight into the origin and progression of a tumour. The germline mutations, either inherited or spontaneous, form the basis for human diversity when neutral, or result in few devastating genetic disorders when harmful.The goal of the study is to develop models based on large cohorts of cancer genomic profiles, to identify regions of the genome or genes that are frequently mutated and to determine if these genomic profiles can predict the outcome.  The focus of studies involving genetic disorders is to understand the nature of large genomic structural variations between ‘normal’ humans. The research also aims to explore the role of large scale CNVs in neurological disorders such as autism, autoimmune disorders such as rheumatoid arthritis and infectious diseases such as West Nile Virus.

Contact Information

Dr. Lakshmi Muthuswamy

lakshmi [dot] muthuswamyatoicr [dot] on [dot] ca

Telephone: 416-673-8592

More Contact Information

Affiliations

2008 - Principal Investigator, Informatics and Bio-computing Program, Ontario Institute for Cancer Research (OICR).
2008 - Adjunct Assistant Professor, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
2003 - 2008Senior Computer Scientist, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
2000 - 2004Adjunct Scientist, Department of Physics, Northeastern University, Boston, Massachusetts.
2000 - 2003R&D Design and Test Manager, Nortel Networks, Wilmington, Massachusetts.
1998 - 2000Postdoctoal Research Associate, Department of Physics, Northeastern University, Boston, Massachusetts.
1997PhD, Engineering Physics, McMaster University, Hamilton.

Research Output

  • Nolan ME, Aranda V, Lee S, Lakshmi B, Basu S, Allred DC, Muthuswamy SK
    The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer
    • Cancer Res. 2008 Oct15;68(20):8201-9
  • Sebat J, Lakshmi B, Malhotra D, Troge J, Lese-Martin C, Walsh T, Yamrom B, Yoon S, Krasnitz A, Kendall J, Leotta A, Pai D, Zhang R, Lee YH, Hicks J, Spence SJ, Lee AT, Puura K, Lehtimäki T, Ledbetter D, Gregersen PK, Bregman J, Sutcliffe JS, Jobanputra V, Chung W, Warburton D, King MC, Skuse D, Geschwind DH, Gilliam TC, Ye K, Wigler M
    Strong association of de novo copy number mutations with autism
    • Science. 2007;316:445-449
  • Hicks J, Krasnitz A , Muthuswamy L, Navin N, Riggs M, Leibu E, Esposito D, Alexander J, Troge J, Grubor V, Reiner A, Healy J, Wigler W, Børresen-Dale A-L, Naume B, Schlicting E, Norton N, Maner S, Lundin P, and Zetterberg A
    Genome Profiles and Survival in Breast Cancer
    • Genome Research. 2006;16:1465–1479
  • Lakshmi B, Hall IM, Egan C, Alexander J, Leotta A, Healy J, Zender L, Spector M, Xue W, Lowe SW, Wigler M and Lucito R
    Mouse genomic Representational Oligonucleotide Microarray Analysis: detection of copy number variations in normal and tumor
    • Proc. Natl. Acad. Sci. USA. 2006 Jul 25;103:11234-11239
  • Sebat J, Lakshmi B, Troge J, Alexander J, Young J, Lundin P, Månér S, Massa H, Walker M, Chi M, Navin N, Lucito R, Healy J, Hicks J, Ye K, Reiner A, Gilliam TC, Trask B, Patterson N, Zetterberg A, Wigler M
    Large-Scale Copy Number Polymorphism in the Human Genome
    • Science. 2004 Jul 23;305: 525-528