Paul Boutros


Today, most cancer patients are treated based on physical characteristics of their tumour -- usually how large it is and how far it has spread. A major part of Dr. Boutros' research is to supplement these traditional clinical criteria with new molecular ones. For example, can we personalize the treatment of lung and breast cancer patients based on mRNA profiles of their tumours? Dr. Boutros is developing novel computational techniques focused on answering this type of question.

Boutros Lab website

Contact Information

Dr. Paul Boutros

paul [dot] boutrosatoicr [dot] on [dot] ca

Telephone: 416-673-8564


Research Output

  • Lalonde E, Ishkanian AS, Sykes J, Fraser M, Ross-Adams H, Erho N, Dunning MJ, Halim S, Lamb AD, Moon NC, Zafarana G, Warren AY, Meng X, Thoms J, Grzadkowski MR, Berlin A, Have CL, Ramnarine VR, Yao CQ, Malloff CA, Lam LL, Xie H, Harding NJ, Mak DY, Chu KC, Chong LC, Sendorek DH, P'ng C, Collins CC, Squire JA, Jurisica I, Cooper C, Eeles R, Pintilie M, Dal Pra A, Davicioni E, Lam WL, Milosevic M, Neal DE, van der Kwast T, Boutros PC, Bristow RG
    Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study
    • Lancet Oncology 2014 15(13):1521-1532
  • Alfaro JA, Sinha A, Kislinger T, Boutros PC
    Onco-proteogenomics: cancer proteomics joins forces with genomics
    • Nature Methods 2014 11(11):1107-1113
  • Weinreb I, Piscuoglio S, Martelotto LG, Waggott D, Ng CK, Perez-Ordonez B, Harding NJ, Alfaro J, Chu KC, Viale A, Fusco N, da Cruz Paula A, Marchio C, Sakr RA, Lim R, Thompson LD, Chiosea SI, Seethala RR, Skalova A, Stelow EB, Fonseca I, Assaad A, How C, Wang J, de Borja R, Chan-Seng-Yue M, Howlett CJ, Nichols AC, Wen YH, Katabi N, Buchner N, Mullen L, Kislinger T, Wouters BG, Liu FF, Norton L, McPherson JD, Rubin BP, Clarke BA, Weigelt B, Boutros PC, Reis-Filho JS
    Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands
    • Nature Genetics 2014 46(11):1166-1169
  • Boutros PC, Ewing AD, Ellrott K, Norman TC, Dang KK, Hu Y, Kellen MR, Suver C, Bare JC, Stein LD, Spellman PT, Stolovitzky G, Friend SH, Margolin AA, Stuart JM
    Global optimization of somatic variant identification in cancer genomes with a global community challenge
    • Nature Genetics 2014;46(4):318-319
  • Chong LC, Albuquerque MA, Harding NJ, Caloian C, Chan-Seng-Yue M, de Borja R, Fraser M, Denroche RE, Beck TA, van der Kwast T, Bristow RG, McPherson JD, Boutros PC
    SeqControl: process control for DNA sequencing
    • Nature Methods 2014 11(10):1071-1075