Paul Boutros


Today, most cancer patients are treated based on physical characteristics of their tumour -- usually how large it is and how far it has spread. A major part of Dr. Boutros' research is to supplement these traditional clinical criteria with new molecular ones. For example, can we personalize the treatment of lung and breast cancer patients based on mRNA profiles of their tumours? Dr. Boutros is developing novel computational techniques focused on answering this type of question.

Boutros Lab website

Contact Information

Dr. Paul Boutros

paul [dot] boutrosatoicr [dot] on [dot] ca

Telephone: 416-673-8564


2015 - OICR Investigator II, Ontario Institute for Cancer Research (OICR).
2013 - Lead, ICGC-TCGA DREAM Somatic Mutation Calling Challenge.
2012 - Assistant Professor, Department of Pharmacology and Toxicology, University of Toronto.
2011 - Assistant Professor, Department of Medical Biophysics, University of Toronto.
2010 - Co-Lead, Canadian Prostate Cancer Genome Network (CPC-GENE).
2010 - 2015OICR Investigator I, Ontario Institute for Cancer Research (OICR).
2008PhD, Department of Medical Biophysics, University of Toronto.
2008 - 2010Fellow, Informatics and Bio-computing, Ontario Institute for Cancer Research (OICR).
2004B.Sc., Chemistry, Honours Co-operative Education, University of Waterloo.
2001 - 2004Bioinformatics Researcher, Department of Pharmacology, University of Toronto.
2000 - 2001Bioinformatics Researcher, Department of Biochemistry, Michigan State University.

Research Output

  • Boutros PC, Fraser M, Harding NJ, de Borja R, Trudel D, Lalonde E, Meng A, Hennings-Yeomans PH, McPherson A, Sabelnykova VY, Zia A, Fox NS, Livingstone J, Shiah YJ, Wang J, Beck TA, Have CL, Chong T, Sam M, Johns J, Timms L, Buchner N, Wong A, Watson JD, Simmons TT, P'ng C, Zafarana G, Nguyen F, Luo X, Chu KC, Prokopec SD, Sykes J, Dal Pra A, Berlin A, Brown A, Chan-Seng-Yue MA, Yousif F, Denroche RE, Chong LC, Chen GM, Jung E, Fung C, Starmans MH, Chen H, Govind SK, Hawley J, D'Costa A, Pintilie M, Waggott D, Hach F, Lambin P, Muthuswamy LB, Cooper C, Eeles R, Neal D, Tetu B, Sahinalp C, Stein LD, Fleshner N, Shah SP, Collins CC, Hudson TJ, McPherson JD, van der Kwast T, Bristow RG
    Spatial genomic heterogeneity within localized, multifocal prostate cancer.
    • Nature Genetics 2015
  • Ewing AD, Houlahan KE, Hu Y, Ellrott K, Caloian C, Yamaguchi TN, Bare JC, P'ng C, Waggott D, Sabelnykova VY; ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants, Kellen MR, Norman TC, Haussler D, Friend SH, Stolovitzky G, Margolin AA, Stuart JM, Boutros PC
    Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection
    • Nature Methods 2015
  • Lalonde E, Ishkanian AS, Sykes J, Fraser M, Ross-Adams H, Erho N, Dunning MJ, Halim S, Lamb AD, Moon NC, Zafarana G, Warren AY, Meng X, Thoms J, Grzadkowski MR, Berlin A, Have CL, Ramnarine VR, Yao CQ, Malloff CA, Lam LL, Xie H, Harding NJ, Mak DY, Chu KC, Chong LC, Sendorek DH, P'ng C, Collins CC, Squire JA, Jurisica I, Cooper C, Eeles R, Pintilie M, Dal Pra A, Davicioni E, Lam WL, Milosevic M, Neal DE, van der Kwast T, Boutros PC, Bristow RG
    Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study
    • Lancet Oncology 2014 15(13):1521-1532
  • Weinreb I, Piscuoglio S, Martelotto LG, Waggott D, Ng CK, Perez-Ordonez B, Harding NJ, Alfaro J, Chu KC, Viale A, Fusco N, da Cruz Paula A, Marchio C, Sakr RA, Lim R, Thompson LD, Chiosea SI, Seethala RR, Skalova A, Stelow EB, Fonseca I, Assaad A, How C, Wang J, de Borja R, Chan-Seng-Yue M, Howlett CJ, Nichols AC, Wen YH, Katabi N, Buchner N, Mullen L, Kislinger T, Wouters BG, Liu FF, Norton L, McPherson JD, Rubin BP, Clarke BA, Weigelt B, Boutros PC, Reis-Filho JS
    Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands
    • Nature Genetics 2014 46(11):1166-1169
  • Chong LC, Albuquerque MA, Harding NJ, Caloian C, Chan-Seng-Yue M, de Borja R, Fraser M, Denroche RE, Beck TA, van der Kwast T, Bristow RG, McPherson JD, Boutros PC
    SeqControl: process control for DNA sequencing
    • Nature Methods 2014 11(10):1071-1075