Paul Boutros


Today, most cancer patients are treated based on physical characteristics of their tumour -- usually how large it is and how far it has spread. A major part of Dr. Boutros' research is to supplement these traditional clinical criteria with new molecular ones. For example, can we personalize the treatment of lung and breast cancer patients based on mRNA profiles of their tumours? Dr. Boutros is developing novel computational techniques focused on answering this type of question.

Contact Information

Dr. Paul Boutros

paul [dot] boutrosatoicr [dot] on [dot] ca

Telephone: 416-673-8564


2010 - OICR Investigator I, Ontario Institute for Cancer Research (OICR).
2008PhD, Department of Medical Biophysics, University of Toronto.
2004B.Sc., Chemistry, Honours Co-operative Education, University of Waterloo.
2001 - 2004Bioinformatics Researcher, Department of Pharmacology, University of Toronto.
2000 - 2001Bioinformatics Researcher, Department of Biochemistry, Michigan State University.

Research Output

  • Fox NS, Starmans MH, Haider S, Lambin P, Boutros PC
    Ensemble analyses improve signatures of tumour hypoxia and reveal inter-platform differences
    • BMC Bioinformatics 2014
  • Boutros PC, Ewing AD, Ellrott K, Norman TC, Dang KK, Hu Y, Kellen MR, Suver C, Bare JC, Stein LD, Spellman PT, Stolovitzky G, Friend SH, Margolin AA, Stuart JM
    Global optimization of somatic variant identification in cancer genomes with a global community challenge
    • Nature Genetics 2014;46(4):318-319
  • Govind SK, Zia A, Hennings-Yeomans PH, Watson JD, Fraser M, Anghel C, Wyatt AW, van der Kwast T, Collins CC, McPherson JD, Bristow RG, Boutros PC
    ShatterProof: operational detection and quantification of chromothripsis
    • BMC Bioinformatics 2014;15(78):1-13
  • Prokopec SD, Watson JD, Waggott DM, Smith AB, Wu AH, Okey AB, Pohjanvirta R, Boutros PC
    Systematic evaluation of medium-throughput mRNA abundance platforms
    • RNA 2013;19(1):51-62
  • Starmans MH, Pintilie M, John T, Der SD, Shepherd FA, Jurisica I, Lambin P, Tsao MS, Boutros PC
    Exploiting the noise: improving biomarkers with ensembles of data analysis methodologies
    • Genome Medicine 2012;4(84):1-12