Imaging for Clinical Trials Platform

The cancer imaging platform project seeks to develop capabilities to:

  • manage the acquisition and analysis of images and generate standardized reports with quantitative measurements that meet clinical trials requirements for existing endpoints (i.e., RECIST);
  • develop and provide imaging viewing and analysis tools to measure novel biomarkers of tumor response suitable for use in clinical trials; and
  • share images in a secure fashion and maintain an imaging registry/databank as a province-wide resource for cancer imaging biomarker research and development.

Many of the new imaging biomarkers target functional and/or molecular parameters of cancer. In order to capitalize on the availability of these imaging biomarkers in clinical trials, networked imaging trials are essential to provide standardized tools for single- or multi-modality image acquisition, image analysis, development of standardized operating procedures and standardized reporting. Centralized imaging review will provide quality assurance for imaging endpoints and the expertise of an Imaging Trials Platform Network (radiologists, scientists, managers, and accredited readers) will make imaging biomarkers more attractive for routine inclusion in cancer clinical trials and provide a competitive advantage for industry trials.

Lead Principal Investigator
Dr. Glenn Bauman, London Regional Cancer Program, London Health Sciences Centre

Principal Investigators
Dr. John Adziovsky, University Health Network
Dr. Aaron Fenster, Robarts Research Institute
Dr. David Jaffray, University Health Network
Dr. Masoom Haider, Sunnybrook Health Sciences Centre
Dr. Harry Keller, University Health Network
Dr. Grace Parraga, Robarts Research Institute
Dr. Ivan Yeung, University Health Network

Collaborators
ClearCanvas

Sub-Projects

  • Development and Validation of Tumour Volumetric Tools: Lung
  • Tumour Perfusion Assessment Methods and Tools: Cervix and Prostate
  • Tools for Multi-Modality Spatio-Temporal Image Analysis
  • Accreditation Lab for Clinical Trials Imaging
  • Image Viewing and Analysis Platform
  • Image Sharing Network/Archive
  • Phantom-Based Calibration and Validation of Imaging Processes
  • Reference Tumour Image Bank