Pathology Validation Project

Overview

The Pathology Validation Project is carried out as a joint project between OICR and the Centre for Imaging Technology Commercialization (CIMTEC). CImTeC serves as the host institution for the Imaging Translation Program and will help to bring many of the developments in this project to commercial fruition. The goals of the Pathology Validation Project are to provide a means for validating novel in vivo imaging tools developed under the Smarter Imaging Program (SIP), to improve the accuracy and capabilities of pathology by improving spatial sampling and making it more quantitative and objective, and to facilitate the quantitative use of biomarkers for informing diagnostic and management decisions in cancer. Our planned activities are an extension of the initial infrastructure and capability that we have built over the past four years and in part will support the activities of the Smarter Imaging Program in probe development and development of imaging techniques for specific cancer sites. The Pathology Validation Project will also work closely with researchers across other OICR programs to help solve problems that require quantitative pathology and biomarker information by developing new techniques or adapting and refining existing ones to the research need.

Sub-Projects

  • Developing a Pipeline for the Correlation of 3D in vivo Imaging to Histopathology;
  • Development of 3D Pathology Techniques for Prostate Cancer;
  • Development of Multiplexed 2D and 3D Pathology Techniques.

Lead Principal Investigator

Dr. Martin Yaffe, Sunnybrook Health Sciences Centre and Centre for Imaging Technology Commercialization