Nadeem Moghal

Principal Investigator

Research Description

Despite major breakthroughs in stem (or progenitor) cell research over the past decade, the specifics of how stem/progenitor cells function in the human body remain largely unknown to scientists.

Dr. Moghal’s lab is trying to shed light on this problem though the study of stem/progenitor cell biology in the human lung. The lab has established a living culture system that allows researchers to isolate and study the expansion and differentiation of normal human bronchial epithelial (NHBE) stem/progenitor cells outside the human body. Currently, the lab employs both standard and high-throughput approaches to characterize the stem/progenitor populations in adult human airways and the pathways that regulate their behaviour.

Ultimately, Dr. Moghal will apply information from these studies into therapies to treat diseases such as lung cancer and cystic fibrosis.

Contact Information

Telephone
+1 (416) 581 7834
Mailing Address
University Health Network - Division of Stem Cell and Developmental Biology
101 College Street
Toronto, Ontario
Canada, M5G 1L7
Additional Contacts
Jenny Kaderali
+1 (416) 581 7835
Stefan Hasenoeder
Stefan Hasenoeder, Research Technician, Ontario Institute for Cancer Research (OICR)
+1 (416) 581 7859
Helen Cheung
Helen Cheung, Postdoctoral Fellow, Ontario Institute for Cancer Research (OICR)
+1 (416) 581 7859
Bo Ram Kim
Bo Ram Kim, Graduate Student, Ontario Institute for Cancer Research (OICR)
+1 (416) 581 7859

Current

2007 - Principal Investigator, Ontario Institute for Cancer Research (OICR).
2007 - Scientist, Ontario Cancer Institute, Division of Stem Cell and Developmental Biology, University Health Network (UHN).
2007 - Assistant Professor, Department of Medical Biophysics, University of Toronto.

Background

2003 - 2007Assistant Professor, Huntsman Cancer Institute/University of Utah, Department of Oncological Sciences.
1998 - 2003Howard Hughes Medical Institute, Pasadena, California. Laboratory of Dr. Paul W. Sternberg, California Institute of Technology.
1996PhD, Harvard University, Microbiology and Molecular Genetics.
1996 - 1998Laboratory of Dr. Benjamin Neel, Boston, Harvard Institutes of Medicine.

Selected Bibliography

  • Modzelewska K*, Elgort MG*, Huang J, Jongeward G, Lauritzen A, Yoon CH, Sternberg PW, Moghal N. An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the EGFR pathway during C. elegans vulval development. Mol Cell Biol. 2007;27(10): 3695-3707. (*These authors contributed equally.)
    • Moghal N*, Garcia LR*, Iwasaki K, Khan L, Sternberg PW. Modulation of EGF receptor-mediated vulva development by the heterotrimeric G-protein Galpha q and excitable cells in C. elegans. Development. 2003;130(19):4553-4566. (*These authors contributed equally.) [Comment in Science. 301(5639):1447.]
      • Moghal N and Sternberg PW. A component of the transcriptional mediator complex inhibits RAS-dependent vulval fate specification in C. elegans. Development. 2003;130(1):57-69.
        • Moghal N and Neel BG. Integration of growth factor, extracellular matrix, and retinoid signals during bronchial epithelial cell differentiation. Mol Cell Biol.1998;18(11):6666-6678.
          • Moghal N and Neel BG. Evidence for impaired retinoic acid receptor-thyroid hormone receptor AF-2 cofactor activity in human lung cancer. Mol Cell Biol. 1995;15(7):3945-3959.