As success with treating pediatric brain cancers has grown, it has also become clear that there are frequently debilitating side effects to the radiation and chemotherapy treatments that have improved survival. These side effects are known to include neurocognitive and behavioural deficits, but the mechanism by which they develop remains unclear. Dr. Nieman’s lab is characterizing the neuroanatomical consequences of treatment that are associated with treatment side effects and investigating genetic factors that might mitigate them.
It is well recognized that cancers are composed of a diverse group of cells. Advances in cancer diagnoses and treatments must account for this heterogeneity and target the cells most responsible for sustaining or repopulating the cancer. Thus, characterizing the distribution of different cell types and determining their activity remain fundamental parts of cancer research. The ability to do so in three-dimensions, and even non-invasively, would greatly improve our understanding of how cancers progress and how cells — both normal and cancer — respond to treatment. Dr. Nieman’s lab is developing imaging methods to achieve this aim, primarily focusing on magnetic resonance imaging and optical imaging technologies.
|2009 -||Scientist, Physiology and Experimental Medicine, The Hospital for Sick Children (Sickkids).|
|2009 -||OICR Investigator II, Ontario Institute for Cancer Research (OICR).|
|2006 -||PhD, Department of Medical Biophysics, University of Toronto.|
|2006 - 2009||Postdoctoral Fellow, Skirball Institute of Biomolecular Medicine, New York University School of Medicine.|
- Nieman BJ, Wong MD, Henkelman RM.
Genes into geometry: imaging for mouse development in 3D
- Curr Opin Genet Dev 2011; 21:638-646
- Nieman BJ, Shyu JY, Rodriguez JJ, Garcia AD, Joyner AL, Turnbull DH
In vivo MRI of neural cell migration dynamics in the mouse brain
- NeuroImage. 2010; In press (doi:10.1016/j.neuroimage.2009.12.107)
- Nieman BJ, Szulc KU, Turnbull DH
Three-dimensional, in vivo MRI with self-gating and image coregistration in the mouse
- Magn Reson Med; 2009; 61:1148-1157
- Nieman BJ, Lerch JP, Bock NA, Chen XJ, Sled JG, Henkelman RM
Mouse behavioral mutants have neuroimaging abnormalities
- Hum Brain Mapp. 2007; 28:567-575
- Nieman BJ, Flenniken AM, Adamson SL, Henkelman RM, Sled JG
Anatomical phenotyping in the brain and skull of a mutant mouse by magnetic resonance imaging and computed tomography
- Physiol Genomics. 2006; 24:154-162