New sequencing technologies have made possible the systematic identification of genetic mutations and other genomic changes in large sample sets. The Genome Technologies Program led by Dr. John McPherson catalogues genetic alterations that occur in different types of cancers to better classify tumours and refine and develop new targeted treatments and diagnostic tools. Pancreatic ductal carcinoma and prostate cancer are major research targets. In addition, the Genome Technologies Program is participating in a pilot project to use next-generation sequencing as a clinical tool in the treatment of cancer.
|2009 -||Chair, Technology Development Advisory Group (TDAG), International Barcode of Life (iBOL) Project.|
|2009 -||Member, Scientific Advisory Board for the Medicago Hapmap Project, National Science Foundation.|
|2007 -||Genome Technologies Director, Ontario Institute for Cancer Research (OICR).|
|2003 - 2007||Associate Professor, Baylor College of Medicine. Primary appointment, Department of Molecular and Human Genetics. Joint appointment, Human Genome Sequencing Center., Baylor College of Medicine.|
|2000 - 2003||Associate Professor, Primary appointment, Division of Biology and Biomedical Sciences, Department of Genetics. Joint appointment, Genome Sequencing Center., Washington University School of Medicine.|
|1999 - 2003||Co-Director, Genome Sequencing Center, Washington University School of Medicine.|
|1993 - 1996||Co-Director, National Human Genome Research Center, University of California at Irvine.|
|1990 - 1992||Postdoctoral Fellow, Department of Biological Chemistry, University of California at Irvine.|
|1989||PhD, Biochemistry, Queen's University.|
|1988 - 1990||Postdoctoral Fellow, Department of Pediatrics, University of California at Irvine.|
- Diamandis E, Voelkerding K, Drmanac R, Agus D, McPherson J
Next-Generation Sequencing: A New Revolution in Molecular Diagnostics? Clin
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Characterizing the cancer genome in lung adenocarcinoma
- Nature Advance Online Publication 2007 November 4;doi:10.1038/nature06358
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Comprehensive DNA methylation profiling in a human cancer genome identifies novel epigenetic targets
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