Dr. Kristin Hope’s research program is focused on dissecting the molecular regulation of hematopoietic stem cell self-renewal. She aims to identify the underlying processes that lead to the transformation of healthy cells into leukemic cells and contribute to the progression of the disease.
In lower organisms such as the fruit fly, cell polarization coupled with the asymmetric inheritance of fate determinants is critical for regenerating the stem cell reservoir while simultaneously ensuring production of all required differentiated cell types. When dysregulated however, these processes contribute instead towards malignant progression and the formation of tumours driven by stem cells that divide unchecked.
Hope’s work will pay particular attention to defining the role that such polarity and asymmetric cell division proteins play in the maintenance and/or expansion of human normal and malignant blood stem cells. With this work she aims to provide advances that will have implications for the development of novel methods to amplify hematopoietic stem cells for use in regenerative therapies or to reign in constitutively self-renewing leukemia cells.
|2010 -||OICR Investigator, Ontario Institute for Cancer Research (OICR).|
|2010 -||Assistant Professor, Biochemistry and Biomedical Sciences, McMaster University, Hamilton.|
|2010 -||Principal Investigator, McMaster Stem Cell and Cancer Research Insititute.|
- Hope KJ* and Sauvageau G*. (2011) *authors made equal contribution.
Roles for MSI2 and PROX1 in hematopoietic stem cell activity
- Curr Opin Hematol. 18(4):203-207
- Hope KJ, Cellot S, Ting S, MacRae T, Mayotte N, Iscove NN, Sauvageau G
An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity
- Cell Stem Cell. 2010;7(1):101-113
- Barabe F*, Kennedy JA*, Hope KJ, Dick JE
Modeling the initiation and progression of human acute leukemia in mice
- Science. 2007;316(5824):600-604
- Jin L*, Hope KJ*, Zhai Q, Smadja-joffe F, Dick JE
Targeting of CD44 eradicates human acute myeloid leukemia stem cells due to abrogation of stem cell trafficking and induction of differentiation
- Nature Medicine. 2006;12(10):1167-1174
- Hope KJ*, Jin L*, Dick JE
Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity
- Nature Immunology. 2003;5(7):738-743