A tumour is a mass of cells that grows uncontrollably and eventually spreads throughout the body. A small subset of cells in the tumour, called cancer stem cells, is responsible for tumor growth. The cancer stem cells act as a “seed”, so that even though they are vastly outnumbered by other cells within the tumour, they are the cells that initiate and maintain the disease. They are also resistant to standard therapies, and thus allow old tumours that have already been treated to return.
By identifying markers to differentiate cancer stem cells from other cells in the human body, Dr. Ailles' lab hopes to develop a greater understanding of how cancer stem cells work. With this understanding researchers will be able to eliminate cancer stem cells and create new therapies that can stop the development of tumours before they become fatal.
Dr. Ailles’ lab will focus primarily on the characterization of cancer stem cells from head and neck squamous cell carcinoma (HNSCC) and ovarian cancer.
|2008 -||OICR Investigator II, Ontario Institute for Cancer Research (OICR).|
|2008 -||Scientist, Division of Stem Cell and Developmental Biology, Ontario Cancer Institute.|
|2007 - 2008||Senior Research Scientist, Stanford University.|
|2005 - 2007||Research Associate, Stanford University.|
|2005||Postdoctoral fellow, Pathology, Stanford University.|
|2001||Postdoctoral fellow, Gene Therapy, Institute for Cancer Research, Candiolo, Italy.|
|1999||PhD, Genetics, University of British Columbia.|
- Ailles L, Weissman IL
Cancer stem cells in solid tumors
- Current Opinion in Biotechnology, 2007;18:460-6.
- Go to Cancer stem cells in solid tumors
- Prince ME, Sivanandan R, Kaczorowski A, Wolf GT, Kaplan MJ, Dalerba P, Weissman IL, Clarke MF, Ailles LE
Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma
- Proc Natl Acad Sci USA. 2007;104:973-8
- Go to Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma
- Tan BT, Park CY, Ailles LE, Weissman IL
The cancer stem cell hypothesis: a work in progress
- Lab Invest. 2006;86:1203-7
- Go to The cancer stem cell hypothesis: a work in progress
- Asset - Jamieson CHM, Ailles LE, Dylla SJ, Muijtjens M, Jones C, Zehnder JL, Gotlib J, Li K, Manz MG, Keating A, Sawyers CL, and Weissman IL
Granulocyte/macrophage progenitors in chronic myelogenous leukemia are candidate leukemia stem cells that activate the beta-catenin pathway
- New England Journal of Medicine, 2004;351:657-67
- Go to Granulocyte/macrophage progenitors in chronic myelogenous leukemia are candidate leukemia stem cells that activate the beta-catenin pathway
- Ailles LE, Naldini L
HIV-derived lentiviral vectors
- Current Topics in Microbiology and Immunology 2002;261:31-52.
- Go to HIV-derived lentiviral vectors