Lincoln Stein


Dr. Lincoln Stein leads the OICR's Informatics and Bio-computing Program, which undertakes the management and analysis of large integrative cancer research projects including the International Cancer Genome Consortium (ICGC) and its Data Coordination Centre. His research focuses on using network and pathway-based analysis to identify common mechanisms in multiple cancer types and to devise prognostic and predictive signatures to aid in patient management. In addition, his group works on problems relating to the genome structure and function of the nematode Caenorhabditis elegans, a model organism that has yielded many insights into cancer.



Contact Information

Dr. Lincoln Stein

lincoln [dot] steinatoicr [dot] on [dot] ca

Telephone: 416-673-8514


1998 - 2004Associate Professor, Cold Spring Harbor, New York.
1997Director Information Systems, CuraGen Corporation.
1995 - 1997Instructor, Harvard Medical School, Dept. of Pathology, Brigham & Women’s Hospital.
1992 - 1997Director, Informatics Core, MIT Genome Center, Whitehead Institute for Biomedical Research, MIT.
1989 - 1992Residency, Anatomic Pathology, Brigham & Women’s Hospital.
1989MD, Harvard Medical School.
1989PhD, Cell Biology, Harvard University.

Research Output

  • Liang C, Jaiswal P, Hebbard C, Avraham S, Buckler ES, Casstevens T, Hurwitz B, McCouch S, Ni J, Pujar A, Ravenscroft D, Ren L, Spooner W, Tecle I, Thomason J, Tung C, Wei X, Yap I, Youens-Clark K, Ware D, Stein L
    Gramene: a growing plant comparative genomics resource
    • Nucleic Acids Research. 2007; 1–7
  • Schmidt CJ, Romanov M, Ryder O, Magrini V, Hickenbotham M, Glasscock J, McGrath S, Mardis E, Stein LD
    Gallus G
    • Browse: a unified genomic database for the chicken. Nucleic Acids Research, 2007; 1–5
  • Vastrik I, D'Eustachio P, Schmidt E, Joshi-Tope G, Gopinath G, Croft D, de Bono B, Gillespie M, Jassal B, Lewis S, Matthews L, Wu G, Birney E, Stein L
    Reactome: a knowledge base of biologic pathways and processes
    • Genome Biology; 2007, 8:R39
  • Chen N, Mah A, Blacque OE, Chu J, Phgora K, Bakhoum MW, Newbury CRH, Khattra J, Chan S, Go A, Efimenko E, Johnsen R, Phirke P, Swoboda P, Marra M, Moerman, Leroux MR, Baillie DL, Stein LD
    Identification of ciliary and ciliopathy genes in Caenorhabditis elegans through comparative genomics
    • Genome Biology. 2006; 7:R126
  • Chen N and Stein LD
    Conservation and functional significance of gene topology in the genome of Caenorhabditis elegans
    • Genome Res. 2006; 16: 606-617