Genome instability, stem cell biology and cancer.
How does a normal cell suddenly embark on a journey towards cancer? Acquisition of mutations in oncogenes and tumor suppressors is thought to be necessary for transformation. Improper maintenance of genome integrity as cells grow and duplicate their DNA can lead to mutations and chromosomal rearrangements seen in tumors. Proper DNA damage response and repair is particularly important in stem cells which are a small pool of long-lived cells that replenish tissue throughout life. Dr. Batada's laboratory uses cutting edge genomic tools to elucidate the causes of genome instability in the context of cellular reprogramming and characterize the similarities between stem cells and cancer biology.
|2013 -||Assistant Professor, Department of Medical Biophysics, University of Toronto.|
|2008 -||OICR Investigator II, Ontario Institute for Cancer Research (OICR).|
|2007 - 2008||Postdoctoral fellow, Department of Genetics, Harvard Medical School (George Church, advisor).|
|2004 - 2006||Postdoctoral fellow, Department of Medical Genetics, University of Toronto (Mike Tyers, advisor) and Department of Biology, University of Bath (Laurence Hurst, advisor).|
|2000 - 2004||PhD, Biophysics, Stanford University.|
- Dulev S, Tkach J, Lin S, Batada NN
SET8 methyltransferase activity during the DNA double strand break response is required for recruitment of 53BP1
- EMBO Reports 2014 (in press)
- AC Planello, J Ji, V Sharma, R Singhania, F Mbabaali, F Müller, JA Alfaro, C Bock, DD DeCarvalho, NN Batada
Aberrant DNA methylation reprogramming during induced pluripotent stem cell generation is dependent on the choice of reprogramming factors
- Cell Regeneration 2014, 3:4 doi:10.1186/2045-9769-3-4
- Ji J, Sharma V, Qi S, Guarch ME, Zhao P, Luo Z, Fan W, Wang Y, Mbabaali F, Neculai D, Esteban MA, McPherson JD, Batada NN.
Antioxidant supplementation reduces genomic aberrations in human induced pluripotent stem cells.
- Stem Cell Reports. 2014 Jan 2;2(1):44-51. doi: 10.1016/j.stemcr.2013.11.004.
- Hussein S*, Batada NN*, Vuoristo S, Ching R, Autio R, Narva E, Ng S, Sourour M, Hamalainen R, Olsson C, Lundin K, Mikkola M, Trokovic R, Peitz M, Brustle O, Bazett-Jones D, Alitalo K, Lahesmaa R, Nagy A and Otonkoski T
Copy number variation and selection during reprogramming to pluripotency