Nizar Batada

Overview

Genome instability, stem cell biology and cancer.

How does a normal cell suddenly embark on a journey towards cancer? Acquisition of mutations in oncogenes and tumor suppressors is thought to be necessary for transformation. Improper maintenance of genome integrity as cells grow and duplicate their DNA can lead to mutations and chromosomal rearrangements seen in tumors. Proper DNA damage response and repair is particularly important in stem cells which are a small pool of long-lived cells that replenish tissue throughout life. Dr. Batada's laboratory uses cutting edge genomic tools to elucidate the causes of genome instability in the context of cellular reprogramming and characterize the similarities between stem cells and cancer biology.

Contact Information

Ms. Stacey Quinn

stacey [dot] quinnatoicr [dot] on [dot] ca

Telephone: 416-673-8519

Affiliations

Research Output

  • Dulev S, Tkach J, Lin S, Batada NN
    SET8 methyltransferase activity during the DNA double strand break response is required for recruitment of 53BP1
    • EMBO Reports 2014 (in press)
  • AC Planello, J Ji, V Sharma, R Singhania, F Mbabaali, F Müller, JA Alfaro, C Bock, DD DeCarvalho, NN Batada
    Aberrant DNA methylation reprogramming during induced pluripotent stem cell generation is dependent on the choice of reprogramming factors
    • Cell Regeneration 2014, 3:4 doi:10.1186/2045-9769-3-4
  • Ji J, Sharma V, Qi S, Guarch ME, Zhao P, Luo Z, Fan W, Wang Y, Mbabaali F, Neculai D, Esteban MA, McPherson JD, Batada NN.
    Antioxidant supplementation reduces genomic aberrations in human induced pluripotent stem cells.
    • Stem Cell Reports. 2014 Jan 2;2(1):44-51. doi: 10.1016/j.stemcr.2013.11.004.
  • Ji J, Ng SH, Sharma V, Neculai D, Hussein S, Sam M, Trinh Q, Church GM, McPherson JD, Nagy A, Batada NN
    Elevated coding mutation rate during the reprogramming of human somatic cells into induced pluripotent stem cells
    • Stem Cells. 2012 Mar;30(3):435-40. doi: 10.1002/stem.1011
  • Hussein S*, Batada NN*, Vuoristo S, Ching R, Autio R, Narva E, Ng S, Sourour M, Hamalainen R, Olsson C, Lundin K, Mikkola M, Trokovic R, Peitz M, Brustle O, Bazett-Jones D, Alitalo K, Lahesmaa R, Nagy A and Otonkoski T
    Copy number variation and selection during reprogramming to pluripotency
    • Nature (in press). 2011 (*equal contributions)