Sachdev Sidhu


How cells grow and how they work depends on signals that are mediated by interactions among proteins in the body. Improper regulation of signaling proteins is associated with the rise and progression of cancer and other diseases. A major area of modern biology is concerned with figuring out how protein networks operate and then using this knowledge to create new therapies to help people living with the disease. The Sidhu lab uses combinatorial libraries to develop synthetic peptides, proteins and antibodies that can be used to track and modulate signaling proteins. These synthetic substances are invaluable tools for elucidating the function of proteins in normal and diseased states and may even be used as cancer therapeutics.

Contact Information

Dr. Sachdev Sidhu

Telephone: 416-946-0863


2008 - OICR Senior Investigator, Ontario Institute for Cancer Research (OICR).
2008 - Associate Professor, Department of Molecular Genetics, University of Toronto.
2008 - Associate Professor, Banting and Best Department of Medical Research, University of Toronto.
1998 - Postdoctoral Fellow Department of Protein Engineering, Genentech, Inc. Supervisor: Dr. James A. Wells, Genentech, Inc.
1996 - PhD, Biochemistry, Simon Fraser University (SFU).
2004 - 2008Senior Scientist, Department of Protein Engineering, Genentech, Inc.
1998 - 2004Scientist, Department of Protein Engineering, Genentech, Inc.

Research Output

  • Tonikian R, Xin X, Toret CP, Gfeller D, Landgraf C, et al
    Bayesian Modeling of the Yeast SH3 Domain Interactome Predicts Spatiotemporal Dynamics of Endocytosis Proteins
    • PLoS Biol. 2009;7(10): e1000218
  • Tonikian R, Zhang Y, Sazinsky SL, Currell B, Yeh J-H, et al
    A specificity map for the PDZ domain family
    • PLoS Biol. 2008;6(9): e239
  • Yeh JH, Sidhu SS, Chan AC
    Regulation of a late phase of T cell polarity and effector functions by Crtam
    • Cell. 2008;132: 846-859
  • Fellouse FA, Esaki K, Birtalan S, Raptis J, Cancasci VJ, Koide A, Jhurani P, Vasser M, Wiesmann C, Kossiakoff AA, Koide S, Sidhu SS
    High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries
    • J. Mol. Biol. 2007;373:924-940
  • Sidhu SS, Fellouse FA
    Synthetic therapeutic antibodies
    • Nature Chem. Biol. 2006;12:682-688.