Timothy Scholl

Overview

As cancer treatments become more individualized, molecular imaging is becoming an increasingly valuable tool to characterize tumours and their response to a specific therapy. Research underway by a group led by Dr. Timothy Scholl at the Imaging Research Laboratories of the Robarts Research Institute is focusing on developing an emergent technique for molecular imaging with magnetic resonance. Using specialized equipment, 13C-enriched endogenous compounds can be magnetized in vitro to a very high degree for injection as novel contrast agents for pre-clinical magnetic resonance imaging. The “hyperpolarized” compound and its metabolites are spatially and temporally imaged to produce a map comparing aspects of cellular metabolism between healthy and diseased tissue. This innovative form of molecular imaging is being used to develop biomarkers for cancer detection, tumour characterization, and monitoring tumour response to treatment.

Contact Information

Darlene Goodine

Telephone: 519-931-5251

Affiliations

2010 - Assistant Professor, Medical Physics (Cross Appointment), Department of Physics and Astronomy, The University of Western Ontario (UWO).
2010 - Assistant Professor, Medical Biophysics, Department of Medical Biophysics, The University of Western Ontario (UWO).
2010 - Associate Scientist, Magnetic Resonance Imaging, The University of Western Ontario Imaging Research Laboratories, Robarts Research Institute (RRI).
2010 - OICR Investigator II, Ontario Institute for Cancer Research (OICR).
1988 - PhD Physics, Department of Physics and Astronomy, The University of Western Ontario (UWO).
2004 - 2009Research Associate, Medical Physics, Department of Physics and Astronomy, The University of Western Ontario (UWO).
1989 - 1990Postdoctoral Fellow, Atomic and Molecular Physics, The University of Western Ontario (UWO).

Research Output

  • Alford JK, Rutt BK, Scholl TJ, Handler WB, Chronik BA
    Delta relaxation enhanced MR: obtaining order of magnitude increases in the activation-specificity of molecular probes through R1 dispersion imaging
    • Magn Reson Med. 2009; 61:796-802
  • Alford JK, Scholl TJ, Handler WB, Chronik BA
    Design, construction, interfacing and benchmarking of a prototype high-power B0 insert coil for field-cycled imaging in a 1.5T superconducting MRI system
    • Concepts in Magn Reson B: Magn Res Eng. 2009; 35B:1-10.
  • Bindseil GA, Handler WB, Scholl TJ, Gilbert KM, Chronik BA
    First hybrid images from a combined PET and field-cycled MRI system
    • Proceedings of the ISMRM 17th Scientific Meeting, Honolulu. 2009:590
  • Gilbert KM, Scholl TJ, Handler WB, Alford JK, Chronik BA
    Evaluation of a positron emission tomography (PET)-compatible field-cycled MRI (FCMRI) scanner
    • Magn Reson Med. 2009; 62:1017-1025
  • Recoskie BJ, Scholl TJ, Chronik BA
    Discrepancy between human peripheral nerve chronaxie times as measured using magnetic and electric field stimuli: relevance to MRI gradient coil safety
    • Phys Med Biol. 2009; 54:5965-5979