Brad Wouters
Overview
Unlike most tissue, tumour cells can survive and thrive in environments starved of oxygen. Characterized by extreme differences in nutrient supply, pH, and oxygenation, these environments promote tumor malignancy and prevent effective treatment for patients.
Dr. Wouters’ lab has identified new signaling pathways that influence how tumours respond to environments with reduced oxygenation. Using high-throughput approaches the lab is defining the molecular basis of these signaling pathways and establishing their importance for future cancer therapies.
Affiliations
Research Output
- Magagnin MG, VandenBeucken T, Sergeant K, Lambin P, Koritzinsky M, Devreese B and Wouters BG
The mTOR target 4E-BP1 contributes to differential protein expression during normoxia and hypoxia through changes in mRNA translation efficiency- 2008;Proteomics:8.
- Koritzinsky M, Rouschop KM, van den Beucken T, Magagnin MG, Savelkouls K, Lambin P, Wouters BG
Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia- Radiother Oncol. 2007;83(3):353-61
- Chiu RK, Brun J, Ramaekers C, Theys J, Weng L, Lambin P, Gray DA, and Wouters BG
Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations- PLOS Genetics. 2006;2:e116
- Koritzinsky M, Magagnin MG, van den Beucken T, Seigneuric R, Savelkouls K, Dostie J, Pyronnet S, Kaufman RJ, Weppler SA, Voncken JW, Lambin P, Koumenis C, Sonenberg N, and Wouters BG
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control- EMBO Journal. 2006;25:1114-1125
- Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Ron D, Wouters BG
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha- Mol Cell Biol. 2002;(21):7405-16