The Ontario Institute for Cancer Research

Dr. John McPherson

Genome Technologies Director

Platform Description

New sequencing technologies have made possible the systematic identification of genetic mutations and other genomic changes. The Genome Technologies Platform led by Dr. John McPherson will begin cataloguing genetic alterations that occur in different types of cancers to better classify tumours and refine and develop new targeted treatments and diagnostic tools.

 

Contact Information

Telephone
416-673-8504

Mailing Address
Ontario Institute for Cancer Research
MaRS Centre, South Tower
101 College Street, Suite 800
Toronto, Ontario
Canada M5G 0A3

Project Manager
Dr. Kamran Shazand
416-673-6657


Current

2009 - Chair: Technology Development Advisory Group (TDAG), International Barcode of Life (iBOL) Project.
2009 - Member: Scientific Advisory Board for the Medicago Hapmap Project, National Science Foundation.
2007 - Genome Technologies Director, OICR.


Background        

2003 - 2007 Associate Professor: Baylor College of Medicine. Primary appointment: Department of Molecular and Human Genetics. Joint appointment: Human Genome Sequencing Center.
2000 - 2003  Associate Professor:  Washington University School of Medicine. Primary appointment: Division of Biology and Biomedical Sciences, Department of Genetics. Joint appointment: Genome Sequencing Center.
1999 - 2003 Co-Director, Genome Sequencing Center: Washington University School of Medicine.
1993 - 1996  Co-Director, National Human Genome Research Center at UCI: University of California at Irvine.
1988 - 1990 Postdoctoral Fellow, University of California at Irvine, Department of Pediatrics.
1990 - 1992 Postdoctoral Fellow, University of California at Irvine, Department of Biological Chemistry.
1989   PhD, Biochemistry, Queen’s University.

 

Selected Publications

  1. Diamandis E, Voelkerding K, Drmanac R, Agus D, McPherson J. Next-Generation Sequencing: A New Revolution in Molecular Diagnostics? Clin. Chem. 2009;55: 1-5.
  2. McPherson JD. Next-Generation Gap. Nature Meth. Supplement, Next-generation sequencing data analysis. 2009; Volume 6, No.11s:S2-S5.
  3. Korshunova Y, Maloney RK, Lakey N, Citek RW, Bacher B, Budiman A, Ordway JM, McCombie WR, Leon J, Jeddeloh JA, McPherson JD. Massively parallel bisulphate pyrosequencing reveals the molecular complexity of breast cancer associated cytosine methylation patterns obtained from tissue and serum DNA.  Genome Res. 2007. Genome Res. 2008; 18:19-29.
  4. Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, Province MA, Kraja A, Johnson LA, Shah K, Sato M, Thomas RK, Barletta JA, Borecki IB, Broderick S, Chang AC, Chiang DY, Chirieac LR, Cho J, Fujii Y, Gazdar AF, Giordano T, Greulich H, Hanna M, Johnson BE, Kris MG, Lash A, Lin L, Lindeman N, Mardis ER, McPherson JD, Minna JD, Morgan MB, Nadel M, Orringer MB, Osborne JR, Ozenberger B, Ramos AH, Robinson J, Roth JA, Rusch V, Sasaki H, Shepherd F, Sougnez C, Spitz MR, Tsao MS, Twomey D, Verhaak RG, Weinstock GM, Wheeler DA, Winckler W, Yoshizawa A, Yu S, Zakowski MF, Zhang Q, Beer DG, Wistuba II, Watson MA, Garraway LA, Ladanyi M, Travis WD, Pao W, Rubin MA, Gabriel SB, Gibbs RA, Varmus HE, Wilson RK, Lander ES, Meyerson M. Characterizing the cancer genome in lung adenocarcinoma.  Nature Advance Online Publication. 2007 November 4;doi:10.1038/nature06358
  5. Ordway JM, Bedell JA, Citek RW, Nunberg A, Garrido A, Kendall R, Stevens JR, Cao D, Doerge RW, Korshunova Y, Holemon H, McPherson JD, Lakey N, Leon J, Martienssen RA, Jeddeloh JA. Comprehensive DNA methylation profiling in a human cancer genome identifies novel epigenetic targets.  Carcinogenesis Epub. 2006 Sep 4;27:2409-2423.

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