The Ontario Institute for Cancer Research

Dr. Nadeem Moghal

Principal Investigator

Research Description

Despite major breakthroughs in stem (or progenitor) cell research over the past decade, the specifics of how stem/progenitor cells function in the human body remain largely unknown to scientists.

Dr. Moghal’s lab is trying to shed light on this problem though the study of stem/progenitor cell biology in the human lung. The lab has established a living culture system that allows researchers to isolate and study the expansion and differentiation of normal human bronchial epithelial (NHBE) stem/progenitor cells outside the human body. Currently, the lab employs both standard and high-throughput approaches to characterize the stem/progenitor populations in adult human airways and the pathways that regulate their behaviour. 

Ultimately, Dr. Moghal will apply information from these studies into therapies to treat diseases such as lung cancer and cystic fibrosis.

Contact Information

Telephone
Office: 416-581-7834
Lab: 416-581-7859

Mailing Address

University Health Network
Division of Stem Cell and Developmental Biology
Ontario Cancer Institute
101 College Street
Toronto Medical Discovery Tower 8-708
Toronto, Ontario
Canada M5G 1L7

Administrative Assistant
Jenny Kaderali
Email: jkaderaluhnresearch.ca
Phone: 416-581-7835

Staff
Stefan Hasenoeder, Research Technician
Email: stefan.hasenoederuhnresearch.ca
Phone: 416-581-7859

Helen Cheung, Postdoctoral Fellow
Phone: 416-581-7859

Bo Ram Kim, Graduate Student
Phone: 416-581-7859


Current

2007 - Principal Investigator, Ontario Institute for Cancer Research.
2007 - Scientist, University Health Network, Ontario Cancer Institute, Division of Stem Cell and Developmental Biology.
2007 - Assistant Professor, Department of Medical Biophysics, University of Toronto.


Background        

2003 - 2007 Assistant Professor, Huntsman Cancer Institute/University of Utah, Department of Oncological Sciences.
1998 - 2003 California Institute of Technology, Howard Hughes Medical Institute, Pasadena, California. Laboratory of Dr. Paul W. Sternberg.
1996 - 1998 Harvard Institutes of Medicine, Boston. Laboratory of Dr. Benjamin Neel.
1996 PhD, Harvard University, Microbiology and Molecular Genetics.

                                             

Selected Publications

  1. Modzelewska K*, Elgort MG*, Huang J, Jongeward G, Lauritzen A, Yoon CH, Sternberg PW, Moghal N.  An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the EGFR pathway during C. elegans vulval development. Mol Cell Biol. 2007;27(10): 3695-3707. (*These authors contributed equally.)
  1. Moghal N*, Garcia LR*, Iwasaki K, Khan L, Sternberg PW. Modulation of EGF receptor-mediated vulva development by the heterotrimeric G-protein Galpha q and excitable cells in C. elegans. Development. 2003;130(19):4553-4566.  (*These authors contributed equally.) [Comment in Science. 301(5639):1447.]
  1. Moghal N and Sternberg PW. A component of the transcriptional mediator complex inhibits RAS-dependent vulval fate specification in C. elegans. Development. 2003;130(1):57-69.
  1. Moghal N and Neel BG. Integration of growth factor, extracellular matrix, and retinoid signals during bronchial epithelial cell differentiation. Mol Cell Biol.1998;18(11):6666-6678.
  1. Moghal N and Neel BG. Evidence for impaired retinoic acid receptor-thyroid hormone receptor AF-2 cofactor activity in human lung cancer. Mol Cell Biol. 1995;15(7):3945-3959.

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