Dr. Christina Yung

Director, Genome Informatics

Dr. Christina Yung leads a team of software engineers, infrastructure specialists and bioinformaticians at OICR to build tools that empower and accelerate cancer research discoveries. Dr. Yung and her team develop data portals and full stack software for ICGC initiatives (including ICGC-ARGO), the Kids First Data Resource Portal and the NCI Genomics Data Commons amongst other big data projects.

Dr. Yung’s previous experience includes managing the Pan-Cancer Analysis of Whole Genomes (PCAWG) Technical Working Group, and the Cancer Genome Collaboratory (CGC). With her interdisciplinary background in bioinformatics, computational biology, machine learning, cancer genomics and cloud computing, Dr. Yung’s work spans multiple scientific disciplines and all cancer types.

Research Interests

  • Software engineering;
  • Data coordination, data management and data portals;
  • Big data infrastructure;
  • Cloud computing.

Select publications

Yung CK*, O’Connor BD*, Yakneen S*, Zhang J,*, Ellrott K, Kleinheinz K, Miyoshi N, Raine KM, Royo R, Saksena GB, Schlesner M, Shorser SI, Vazquez M, Weischenfeldt J, Yuen D, Campbell PJ, Davis-Dusenbery BN, Eils R, Ferretti V, Grossman RL, Harismendy O, Kim Y, Nakagawa H, Newhouse SJ, Torrents D, Stein LD on behalf of the PanCancer Analysis of Whole Genomes Technical Working Group and the PanCancer Analysis of Whole Genomes Network.
Large-Scale Uniform Analysis of Cancer Whole Genomes in Multiple Computing Environments.
2017; In press. doi: https://doi.org/10.1101/161638.

Seong BKA, Fathers KE, Hallett R, Yung CK, Stein LD, Mouaaz S, Kee L, Hawkins CE, Irwin MS, Kaplan DR.
A metastatic mouse model identifies genes that regulate neuroblastoma metastasis.
Cancer Res. 2017; 77(3):696-706.

Notta F, Chan-Seng-Yue M, Lemire M, Li Y, Wilson GW, Connor AA, Denroche RE, Liang S, Brown AMK, Kim JC, Wang T, Simpson JT, Beck T, Borgida A, Buchner N, Chadwick D, Hafezi-Bakhtiari S, Dick JE, Heisler L, Hollingsworth MA, Ibrahimov E, Jang GH, Johns J, Jorgensen LGT, Law C, Ludkovski O, Lungu I, Ng K, Pasternack D, Petersen GM, Shlush LI, Timms L, Tsao M, Wilson JM, Yung CK, Zogopoulos G, Bartlett JMS, Alexandrov LB, Real FX, Cleary SP, Roehrl MH, McPherson JD, Stein LD, Hudson TJ, Campbell PJ, Gallinger S.
A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns.
Nature. 2017; 542(7639):124.

Denroche RE, Mullen L, Timms L, Beck T, Yung CK, Stein L, McPherson JD, Brown AM.
A cancer cell-line titration series for evaluating somatic classification.
BMC Res Notes. 2015; 8:823.

Deshwar AG, Vembu S, Yung CK, Jang GH, Stein L, Morris Q.
PhyloWGS: reconstructing subclonal composition and evolution from whole-genome sequencing of tumors.
Genome Biol. 2015; 16:35.

* Authors contributed equally.

See Dr. Yung’s recent publications on PubMed.

Tools

Overture – an open-source software suite to build data portals.

Previous experience and education

  • Director of Data Commons, Center for Data Intensive Science, University of Chicago;
  • Leader, Technical Working Group, PanCancer Analysis of Whole Genomes (PCAWG), OICR;
  • Project Manager, Cancer Genome Collaboratory, OICR;
  • Informatics Manager, Genome Analysis, OICR;
  • MSc and PhD, Biomedical Engineering, Johns Hopkins University.

Related links

Opportunities to collaborate

To collaborate with Dr. Yung or her Genome Informatics team, please contact her directly.

Visit OICR’s Collaborative Research Resources directory for more opportunities to collaborate with OICR researchers.

Contact

Dr. Christina Yung
Christina.Yung@oicr.on.ca