Dr. David LeBrun

Leader, Ontario Molecular Pathology Research Network

Dr. LeBrun’s research group studies perturbations in the regulation of gene transcription that underlie acute lymphoblastic leukemia (ALL). In particular, his group has been elucidating protein-protein interactions and patterns of genomic binding associated with the oncogenic transcription factor E2A-PBX1 (also called TCF3-PBX1). They also perform correlative research aimed at identifying prognostic and predictive biomarkers in malignant lymphoma, particularly follicular lymphoma and diffuse large B-cell lymphoma.

Current affiliations

  • Leader, Ontario Molecular Pathology Research Network;
  • Principal Investigator, Queen’s Cancer Research Institute;
  • Professor, Department of Pathology and Molecular Medicine, Queen’s University;
  • Academic Director, Queen’s Laboratory for Molecular Pathology.

Research interests

  • Acute lymphoblastic leukemia;
  • Lymphoma;
  • Gene transcription;
  • E2A-PBX1;
  • Chromatin;
  • Genomics;
  • Immunohistochemistry;
  • Tissue microarrays;
  • Multi-spectral immunofluorescence;
  • Gene expression profiling.

Select publications

AlJohani N, Choi SJ, Day AG, Alhejaily A, Virk S, Baetz T, LeBrun DP.
Abundant expression of BMI1 in follicular lymphoma is associated with reduced overall survival.
Leuk Lymphoma. 2018; 59(9):2211-2219.

Weberpals JI, Amin MS, Chen BE, Tu D, Spaans JN, Squire JA, Eisenhauer EA, Virk S, Ma D, Duciaume M, Hoskins P, LeBrun DP.
First application of the Automated Quantitative Analysis (AQUA) technique to quantify PTEN protein expression in ovarian cancer: a correlative study of NCIC CTG OV.16.
Gynecol Oncol, 2016;140(3):486-93.

Woodcroft M, Nanan K, Thompson P, Tyryshkin K, Smith SP, Slany RK, LeBrun DP.
Retrovirus-mediated expression of E2A-PBX1 blocks lymphoid fate but permits retention of myeloid potential in early hematopoietic progenitors.
PLoS One. 2015;10(6):e0130495.

Alhejaily A, Day AG, Feilotter HE, Baetz T, LeBrun DP.
Inactivation of the CDKN2A tumour suppressor gene by deletion or methylation is common at diagnosis in follicular lymphoma and associated with poor clinical outcome.
Clin Cancer Res. 2014;20(6):1676-86.

Denis CM, Chitayat S, Plevin MJ, Wang F, Thompson P, Liu S, Spencer HL, Ikura M, LeBrun DP, Smith SP.
Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX1. 
Blood. 2012;120(19):3968-77.

See Dr. LeBrun’s recent publications on PubMed.

Previous experience and education

  • MD, Queen’s University;
  • Residency, Anatomical Pathology, University of Toronto;
  • Postdoctoral fellowship in molecular oncology, Stanford University.

Opportunities to collaborate

LeBrun’s group is open to many types of collaboration. For example, they have assembled cohorts of cases of follicular lymphoma or diffuse large B-cell lymphoma from their institution. Pre-treatment FFPE biopsy samples are represented on tissue microarrays and baseline and outcome clinical data are available on all cases.

Visit OICR’s Collaborative Research Resources directory for more opportunities to collaborate with OICR researchers.

Related links

Contact

Dr. David LeBrun
david.lebrun@queensu.ca