Dr. John McPherson
Dr. John McPherson is an OICR associate researcher specializing in genome technologies. His research group, based at the University of California, Davis, is interested in:
- understanding the mechanisms underlying structural rearrangements in tumors;
- bringing advanced genomic technologies to clinical application in personalized diagnosis and targeted therapeutics through maximizing the data yield from small biopsies and circulating cell free DNA; and
- reducing chemotherapy-induced side effects during cancer treatment.
- OICR Associate, OICR
- Deputy Director and Associate Director for Basic Science at UC Davis Comprehensive Cancer Center
- Member: University of California Cancer Research Coordinating Committee
- Member: Program Committee for Advances in Genome Biology and Technology Annual Meeting
- Member: International Scientific Steering Committee, International Cancer Genome Consortium
- Nattestad M, Goodwin S, Ng K, …, McPherson JD, …, Schatz MC. Complex rearrangements and oncogene amplifications revealed by long-read DNA and RNA sequencing of a breast cancer cell line. Genome Res. 2018; 28(8):1126-1135.
- Riess JW, Gandara DR, Frampton GM, …, McPherson JD, …, Schrock AB. Diverse EGFR Exon 20 Insertions and Co-Occurring Molecular Alterations Identified by Comprehensive Genomic Profiling of NSCLC. J Thorac Oncol. 2018; 13(10):1560-1568.
- Kiuru M, Tartar DM, Qi L, …, McPherson JD, …, Fung MA. Improving classification of melanocytic nevi: BRAF V600E expression associated with distinct histomorphologic features. J Am Acad Dermatol. 2018; 79(2):221-229.
- Shlush LI, Mitchell A, Heisler L, …, McPherson JD, …, Dick JE. Tracing the origins of relapse in acute myeloid leukaemia to stem cells. Nature. 2017; 547(7661):104-108.
- Wang D, Pham N-A, Tong J, …, McPherson JD, …, Tsao M-S. Molecular heterogeneity of non-small cell lung carcinoma patient-derived xenografts closely reflect their primary tumors. Int J Cancer. 2017; 140(3):662-673.
- Fraser M, Sabelnykova VY, Yamaguchi TN, …, McPherson JD, Bristow RG1, Boutros PC. Genomic hallmarks of localized, non-indolent prostate cancer. J Urol. 2017; 198(6):1213.
- Taylor RA, Fraser M, Livingstone J, …, McPherson JD, …, Bristow RG. Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories. Nature Commun. 2017; 8:13671.
- Notta F, Chan-Seng-Yue M, Lemire M, …, McPherson JD, …, Gallinger S. A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns. Nature. 2016; 538(7625):378-382.
- Goodwin S, McPherson JD, McCombie RW. Coming of Age: Ten years of Next-Generation Sequencing Technologies. Nat Rev Genet. 2016; 17(6):333-51.
- University of California at Irvine, Biotechnology Training Grant Fellowship, 1991
- Queen’s University at Kingston, Queen’s Graduate Award, 1984-1985
- Queen’s University, S. McLaughlin Fellowship, 1985-1988
Previous experience and education
- Genome Technologies Director, Ontario Institute for Cancer Research
- Associate Professor, Baylor College of Medicine. Primary appointment, Department of Molecular and Human Genetics. Joint appointment, Human Genome Sequencing Center., Baylor College of Medicine
- Associate Professor, Primary appointment, Division of Biology and Biomedical Sciences, Department of Genetics. Joint appointment, Genome Sequencing Center., Washington University School of Medicine
- Co-Director, Genome Sequencing Center, Washington University School of Medicine
- Co-Director, National Human Genome Research Center, University of California at Irvine
- Postdoctoral Fellow, Department of Biological Chemistry, University of California at Irvine
- Biochemistry, Queen’s University
- Postdoctoral Fellow, Department of Pediatrics, University of California at Irvine
Opportunities to collaborate
Dr. McPherson is based at UC Davis in Sacramento, California. To collaborate with Dr. McPherson, please contact him directly.
Visit OICR’s Collaborative Research Resources directory for more opportunities to collaborate with OICR researchers.
Dr. John McPherson