Biostatistics Training Initiative

Leaders

Dr. Richard Cook, University of Waterloo
Dr. Gregory Pond, McMaster University

Background

Recent technological advances have led to far more complex and much larger datasets in cancer research. There is a critical need for biostatisticians who can work with these data, ensuring they can be used to inform on the next generation of cancer treatments. Since 2010, the Biostatistics Training Initiative (BTI), previously known as the Oncology Research Training and Methods Program (ORTMP), has placed Master’s students from the University of Waterloo in eight-month internships with mentors at Ontario cancer centres. In doing so, the BTI is training the next generation of biostatisticians in the province, ensuring they are equipped with the technical knowledge, skill set and experience to deal with the changing landscape of cancer treatment and clinical trials.

Based on the success of the program in its first five years and feedback from the Ontario research community regarding its continued need for training, expertise and placement, the BTI expanded in 2016. The new expanded BTI engages a broader group of trainees, including PhDs and postdoctoral fellows, and fosters a sense of community amongst participants through a visiting lecture and monthly seminar series.

The BTI is funded through the Ontario Institute for Cancer Research.

Internships

The BTI Internship Program is a continuation of the earlier OICR-funded ORMTP in which selected top Master’s students in Biostatistics from the University of Waterloo are placed in eight-month internship positions in cancer research centres across Ontario with joint mentorship by a biostatistician and an oncology researcher. Up to four fully funded placements will be made each year from 2016-2020.

For further information and instructions to apply, please visit https://uwaterloo.ca/biostatistics-training-initiative/internship

Fellowships

The BTI Fellowship Program is designed to support doctoral and postdoctoral training in biostatistics for cancer research. The primary objective of the Program is to support the training of the next generation of biostatisticians in the province, ensuring they are equipped with the technical knowledge, skill set and capability for the application of rigorous quantitative methods for cancer research. Through the receipt of a BTI Studentship/Fellowship Award, biostatistics or statistics doctoral students and postdoctoral fellows at an Ontario university will engage in interdisciplinary, collaborative cancer research with investigators located at an Ontario Host Institution.

Any questions about these awards or how to apply may be emailed to scientificsecretariat@oicr.on.ca.

Seminar series

A monthly seminar series will be held by WebEx/teleconferencing on advanced issues in clinical and population health advances, as well as methodological challenges arising in cancer research. The aim is to engage clinicians, statisticians, interns and fellows. The focus of the seminars will include:

  1. recently completed high impact trials in oncology within the group and internationally,
  2. recent developments in the design and analysis of cancer clinical trials,
  3. biostatistical and more general methodological challenges arising in the planning or conduct of trials, and
  4. reports of ongoing methodological research conducted by engaged faculty, students and interns.

BTI Fellowship Program

The BTI Fellowship Program is a new and exciting initiative designed to support doctoral and postdoctoral training in biostatistics for cancer research. The primary objective of the Program is to support the training of the next generation of biostatisticians in the province, ensuring they are equipped with the technical knowledge, skill set and capability for the application of rigorous quantitative methods for cancer research. BTI Fellows will engage in interdisciplinary, collaborative cancer research with investigators located at an Ontario Host Institution.

BTI Fellowship Program

The BTI Fellowship Program is designed to support doctoral and postdoctoral training in biostatistics for cancer research. The primary objective of the Program is to support the training of the next generation of biostatisticians in the province, ensuring they are equipped with the technical knowledge, skill set and capability for the application of rigorous quantitative methods for cancer research. Through the receipt of a BTI Studentship / Fellowship Award, biostatistics or statistics doctoral students and postdoctoral fellows at an Ontario university will engage in interdisciplinary, collaborative cancer research with investigators located at an Ontario Host Institution.

BTI Studentship / Fellowship Award

For the February 2017 Call for Applications, one award valued at $15,000 per year for each of two years will be made available. All funds from this award must be used to support a doctoral student or postdoctoral fellow conducting biostatistical or statistical research which has an application to a problem in oncology.

Applicants

Eligible applicants include:

  • Students currently enrolled in the second or higher year of a Biostatistics or Statistics doctoral program at an Ontario university; or
  • Current Postdoctoral Fellows in Ontario or individuals beginning a postdoctoral position in Ontario within six months of the application deadline; fellows must have completed doctoral training in biostatistics or statistics; or
  • Biostatistics or statistics faculty member at an Ontario university, with a strong background in cancer research, who plan to supervise a biostatistics or statistics doctoral student or postdoctoral fellow.

Application deadline

Applications, composed of completed Form I, letters of support, biosketch and curriculum vitae (CV), must be submitted to scientificsecretariat@oicr.on.ca by 5 p.m. EST on April 14, 2017. Additional details are available in the Applicant Guide.

The award is expected to be announced in early May 2017 with funds available by June 1, 2017

For any questions please contact Teresa.petrocelli@oicr.on.ca

Biostatistics Training Initiative Seminar Series

May 30
Speaker: Eleanor Pullenayegum, Sick Kids

Title: Multiple outputation for longitudinal data subject to irregular observation

Abstract: Observational cohort studies often feature longitudinal data subject to irregular observation. Moreover, the timings of observations may be associated with the underlying disease process and must thus be accounted for when analysing the data. Multiple outputation, which consists of repeatedly discarding excess observations, can be a helpful way of approaching the problem.

Learning objectives:

  • Explain why irregular observation can be a problem
  • Understand different visiting patterns
  • Choose an appropriate analysis for a given visiting pattern

Future Seminars

Locations

Ontario Institute for Cancer Research
West-Tower Boardroom 6-12
MaRS Centre
661 University Avenue, Suite 510,
Toronto, Ontario

Juravinski Hospital and Cancer Centre
G Wing, 2nd floor boardroom
711 Concession St,
Hamilton, Ontario

University of Waterloo
M3 3001
200 University Avenue West
Waterloo, Ontario

Online

To join the webinar:

  1. Go to
    https://cc.callinfo.com/r/19l8gvfikoh7i&eom (not currently compatible with Microsoft Edge)
  2. Enter your name, email address, and click “Join Now”. No password is required.

To join the teleconference: Dial-in:1.800.503.2899, access code: 2484428

In advance of the seminar, we strongly recommend testing the WebEx application to ensure your computer is compatible. To do so, use https://www.webex.com/test-meeting.html to launch the test. You will be required to enter your name and email address. It will then run a test WebEx meeting advising if it was successful. Should you experience technical difficulty, please contact your IT administrator.

Please have your phone lines muted for the duration of the call. You may unmute them at question period

We look forward to your participation.

Past Seminar Series

April 25

Laurent Briollais
Lunenfeld Mount Sinai

Title:
A novel region-based Bayesian approach for genetic association with next generation sequencing (NGS) data coverage.

Abstract:
The discovery of rare genetic variants through Next Generation Sequencing (NGS) is becoming a very challenging issue in the human genetic field. We propose here a novel region-based statistical test based on a Bayes Factor (BF) approach to assess evidence of association between a set of rare variants located on this region and a disease outcome. Marginal likelihood is computed under the null and alternative hypotheses assuming a binomial distribution for the rare variants count in the region. A Beta distribution or a mixture of Dirac and Beta distribution is specified for the prior distribution. The hyper-parameters are determined to ensure the null distribution of BF does not vary across genes with different sizes. A permutation test or False Discovery Rate (FDR) statistic are used for inference. Our simulations studies showed that the new BF statistic outperforms standard methods under most situations considered. Our real data application to a lung cancer study found enrichment for rare variants in novel genes.


Tuesday March 28, 2017

Luyao Ruan – Juri Reimand, OICR

Title:
Neural Network Model for Copy Number Data

Abstract:
In my presentation, I will mainly discuss the project that I worked on during my co-op at the Ontario Institute for Cancer Research. The project focuses on using convolutional neural networks to classify
copy number variation data of Medulloblastoma cancer samples into different subgroups. I will also mention some future directions for the project and discuss some of my other experiences and achievements
during the co-op.


Qihuang Zhang – Wei Xu, UHN

Title:
The Influence of Genetic Variation on the Association Between Statin and Prostate Cancer Risk: A Genome-wide Association Study

Abstract:
During my eight-month internship at Princess Margaret Hospital, I had picked up experience in real oncology clinical studies, data quality control, data analysis, scientific report and manuscript writing. In this talk, I will mainly share my experience in a Genome-wide Association Study (GWAS), cooperated with principal investigator Dr. Rob Hamilton. Genome-wide association study is a statistical examination of a genome-wide set of genetic variants (represented by Single-nucleotide polymorphism, or SNPs) in different individuals to see if any variation is associated with a trait. In the initial study, 3651 prostate cancer patients were included. 533,631 SNPs were collected, and the number was extended to 6,873,954 after doing genotype imputation. A genetic quality control was conducted to remove the individuals and SNPs that were not eligible for the study. The removing criteria included the missing minor allele frequency, outlying heterozygosity rate and correlations among individuals. We constructed additive interaction model and applied it to case-control outcomes by scanning through the whole genome. The results of the study can provide clinical practitioners with a guidance of personalized medicine when giving treatment to prostate cancer patients.


Ri Tong (Rick) Wang – Melania Pintilie, UHN

Title:
Therapeutic Somatostatin Analogs Effect on FGFR4 Polymorphic Alleles

Abstract:
In my presentation, I will elaborate on my general experiences as a biostatistics intern at PMH. In particular, I will focus on the work and challenges leading up to the publication of the paper “FGFR4 polymorphic alleles modulate mitochondrial respiration: A novel target for somatostatin analog action in pituitary tumors”; a paper which compares effects of different somatostatin analogs for FGFR4 codon 388 SNPs.


Erle Holgersen – Paul Boutros, OICR

Title:
Prostate Cancer Heterogeneity and Assorted Chi-Squared Tests

Abstract:
In this presentation I will talk about my work as a biostatistics intern at OICR. I will reflect on learning outcomes of the internship and challenges associated with working as a statistician in a bioinformatics lab. The talk will include examples from a study on the heterogeneity of radioresistant prostate tumours.

All speakers are Master’s students in the Biostatistics graduate program at the University of Waterloo

Tuesday February 28, 2017

Dr. David Berman, MD, PhD
Director, Queen’s Cancer Research Institute, Queen’s University

Biomarkers for Treatment Stratification in Early Prostate Cancer

Abstract:
One in 8 men will be diagnosed with prostate cancer in his lifetime. The vast majority of these men will suffer no harm from this disease, but a small minority (ca. 15%) will die of metastatic cancer spread. The field of prostate cancer care has shifted from over-diagnosis and over-treatment of harmless prostate cancers to a less aggressive stance that de-emphasizes broad screening and offers deferred treatment (active surveillance) for men with cancers that are deemed to have a low risk of metastasis. Unfortunately, risk assessment is highly inaccurate, due to challenges in prostate cancer imaging, biopsy, and pathologic evaluation. This presentation will discuss clinical, pathologic, and molecular features associated with low risk prostate cancer, and attempts to improve risk assessment using molecular features.


Tuesday, January 24, 2017

Dr. Rinku Sutradhar
Senior Scientist, Institute for Clinical Evaluative Sciences

TExamining cancer screening adherence in Ontario using multistate transitional models.

Abstract:
Understanding disparities among women in breast cancer screening adherence is of considerable interest, however prior work has been methodologically limited. Our work longitudinally examines adherence to screening, and determines factors associated with becoming adherent. The cohort consisted of 2, 537, 960 women age 50-74 from Ontario, Canada. Using age as the time scale, a relative rate multivariable regression was implemented under the 3-state transitional model to examine the association between covariates (all time-varying) and the rate of becoming adherent. Individual- and physician-level characteristics played an important role in a woman’s adherence to screening. Our research improves the quality of evidence regarding disparities among women in adherence to breast cancer screening, and provides a novel methodological foundation to investigate adherence for other types of cancer screening, including cervix and colorectal cancer screening.


Tuesday December 13, 2016

Methodology to Identify Environmental and Host Genomic Association on Human Microbiome Data
Dr. Wei Xu
Assistant Professor, University of Toronto, Dalla Lana School of Public Health

Abstract:
Technological advances in genomic sequencing have enabled researchers to unveil the wide variability of bacteria presented within different locations of the body, i.e. the microbiome, and how it relates to disease. However, our understanding of how microbiomes affect diseases is still unclear. It is necessary to better understand both environmental and host genetic factors impact the composition of the microbiome to improve disease management. Powerful statistical and bioinformatics tools are needed to overcome these knowledge gaps.


Friday November 25, 2016

Phase II Study Design in Oncology Drug Development
Dr. Wendy Parulekar, MD
Senior Investigator, Cancer Clinical Trials Group, Queens University

BTI title slide from Friday November 25
Download the slides

Abstract:
The Phase II trial has a pivotal role in drug development since the decision to proceed with further evaluation of a drug/ drug combination is based on the efficacy and safety data generated from this type of study. Important additional generated from the Phase II trial may include elucidation of the mechanism of action of a new therapy and delineation of the target population for administration. The objectives of this webinar are to provide the clinician perspective on Phase II trial design and conduct including classification of designs and statistical framework. Examples of actual clinical trials will be drawn from the casebook of the Canadian Cancer Trials Group.


Friday September 23, 2016

The Challenges of Making Clinically Useful Biomarkers
Dr. Paul Boutros, PhD
Principal Investigator, Informatics and Bio-computing Platform, OICR
Assistant Professor, Department of Medical Biophysics, University of Toronto

Abstract:
Biomarkers are a core part of personalized medicine. They give patients and their clinicians insight about possible future, increasing their confidence in the decisions they make. They also provide regulators and health-care funders confidence that care is being delivered cost-effectively and maximizing outcomes for the entire population. Creating such biomarkers from the many large emerging genomic datasets is surprisingly difficult. There are problems in optimizing experimental design, in fully leveraging large biological data, and in ultimately validating and generalizing the models. We will talk about all these issues, using recent successful genomic biomarkers in prostate cancer as a guiding example.


June 24 2016

Life as a biostatistician
Bethany Pitcher, MSc
Biostatistician, Princess Margaret Cancer Centre

Abstract:
The role of a biostatistician is not limited to the analysis of data. As with many careers, schoolwork lays the foundation for your skills, but does not fully prepare you for the varied ways you will apply these skills in the workplace. I will discuss some of the unique challenges and unexpected aspects of working as a biostatistician that I encountered during my internship and after graduation. I hope to give current students an idea of what they can expect from a career in Biostatistics. I will also discuss my experience as an intern in the Biostatistics Training Initiative and highlight one project I worked on throughout my placement at Princess Margaret Cancer Centre. For this project we performed a meta-analysis of control-arm data from multiple clinical trials available on the Project Data Sphere database. The goal was to determine if any concomitant medications were associated with prognosis in patients with metastatic prostate cancer.


May 20 2016
Patient Reported Outcome Measures (PROMs) for use with children and adolescents: a view across disciplines.
Gillian Lancaster, PhD
Lancaster University, United Kingdom

BTI Title slide
Download the slides


April 22 2016

How clinical trial design pitfalls slow progress against cancer

David J. Stewart, MD
Head, Division of Medical Oncology, University of Ottawa/The Ottawa Hospital

Title slide for How clinical trial design pitfalls slow progress against cancer
Download the slides


April 1 2016

The analysis of progression-free survival, overall survival and markers in cancer clinical trials
Richard Cook, PhD
Professor of Statistics, Department of Statistics and Actuarial Science, University of Waterloo

Watch the video

Abstract:
Cancer clinical trials are routinely designed on the basis of event-free survival time where the event of interest may represent a complication, metastasis, relapse, or progression. This talk is concerned with a number of statistical issues arising from the use of such endpoints including the interpretation of results based on composite endpoints, the consequences of naïve analysis of event times subject to dual censoring schemes, and the causal interpretation of treatment effects. Related issues in the joint analysis of longitudinal and survival data will also be highlighted.