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BioLab

BioLab at OICR is a shared instrumentation division that provides advanced state-of-the-art equipment, tools and technical know-how to support lab research activities for OICR researchers and collaborators.

BioLab Event

June 2811 a.m.

BioLab and Drug Discovery group at OICR are excited to co-host educational webinar “Targeted Protein Screening for Biomarker Discovery” introducing  Olink proteomics technology

Dr. Michael Förster, Scientific Director Oncology and Rare Diseases, Olink Proteomics, will talk about the use and applications of this technology in cancer research.

Join this event remotely via Microsoft Teams

The mission of BioLab is to educate, enable and inspire OICR researchers and collaborators to achieve their research objectives and professional development goals by providing instrument access, knowledge transfer and continued education on advanced cancer technologies and innovations.

BioLab provides its educational offerings through three main intersecting activities:

  • BioLab provides access to advanced technology and leading-edge instrumentation, tools and supports training that brings new knowledge and skills.
  • To maximize the exposure to current knowledge in transdisciplinary cancer research, BioLab offers participation in the networks of science communication such as online webinars and virtual events.
  • BioLab fosters educational collaboration between researchers and technology providers by sharing knowledge, resources and expertise for faster and more effective communication and learning.

BioLab Hub

To better assist OICR researchers during the COVID-19 pandemic, BioLab has extended its educational offerings by launching the BioLab Hub initiative.

BioLab Hub posts bi-weekly selections of free webinars and virtual events (symposiums, conferences, and summits) on new technologies, instrumentation, applications and innovations related to cancer research.

Upcoming Webinars and Virtual Events

Navigate the technology landscape in predictive genomics: An introduction to key technology concepts and strategies
June 21, 2022 | 11:00 a.m. EDT

Predictive genomics is a powerful capability to help predict disease risk and understand drug response in order to improve health outcomes and manage costs. This presentation will provide an overview of genome-wide sequencing and genotyping strategies for predictive genomics research. We will introduce three key whole-genome technologies: whole-genome sequencing (WGS), low-pass sequencing (LPS) and genome-wide AxiomTM microarrays, and discuss how they can be integrated into technology strategies across various applications of predictive genomics research. In this webinar, Dr. Anu Mittal will:(1)Provide an overview of the different technologies:

Whole-genome sequencing (WGS), Low-pass sequencing (LPS), and Axiom Microarrays and (2) Explore how the different technologies can be integrated into strategies across various applications of predictive genomics research.

Digital Ready Slides
June 21, 2022 | 11:00 a.m. EDT

The adoption of digital pathology is a multifaceted project involving many stakeholders across the pathology department. The impact on the laboratory is not isolated to simply installing a scanner but rather affects the whole workflow to generate optimized Digital Ready Slides. Standardization of histological slide preparation requires focusing on optimizing individual workflow steps and a holistic overview of the complete process from sample acquisition right through to diagnosis. Knowing this in advance and taking appropriate steps to effectively change management can promote engagement and pave a path to success.

To Spatial Biology Infinity and Beyond: Discovering Novel Multiomic Possibilities
June 21, 2022 | 11:00 a.m. EDT

Proteomic spatial biology solutions at single-cell resolution have provided an unprecedented understanding of disease biology and have become a prominent fixture across discovery, translational, and clinical research. Moreover, transcriptomic analyses have allowed scientists to analyze whole transcriptomes with RNA-seq, and single-cell RNA sequencing making it possible to profile gene expression in individual cells. The insights gathered from spatial proteomics and transcriptomics have individually provided massive contributions to tissue biology over several decades. A spatial multi-omic approach, which integrates single-cell spatial proteomic data with single-cell spatial transcriptomics, creates an exponentially larger set of possibilities.

Delivering Single-Molecule Proteomics at Scale using Protein Identification by Short epitope Mapping
June 21, 2022 | 1:00 p.m. EDT

The proteome is perhaps the most dynamic and valuable source of functional biological insight. This webinar will introduce a novel single-molecule proteomic analysis approach that includes novel biochemistry for single, intact protein molecule immobilization, instrumentation for highly sensitive iterative probing of those protein molecules with a diverse array of affinity-reagents, and machine learning for data interpretation. The approach is called Protein Identification by Short-epitope Mapping (PrISM). PrISM utilizes multi-affinity reagents to target short linear epitopes to overcome the typical challenges of single-reagent sensitivity and specificity and achieve accessible and reproducible sensitivity and scale. PrISM further employs a novel protein decoding algorithm that considers the stochasticity expected for single-molecule binding.

 

Analyzing Highly Multiplexed and Multi-Modal Spatial-Omics ChipCytometry™ Datasets
June 22, 2022 | 2:00 p.m. EDT

ChipCytometry™ is a technique for collecting and analyzing highly multiplexed spatial cytometry data that has been established since 2009, and commercialized since 2016 with the ZellScannerOne™ instrument. Introduction of the CellScape™ instrument in the Spring of 2022 now affords ChipCytometry users high capacity, higher resolution, and full automation. Here, we will explore the utility of the ChipCytometry dataset through a set of sample analysis pipelines. First, the pipeline native to the CellScape and ZellScannerOne is a generalized image analysis and cytometry method providing immediate access to highly multiplexed spatial datasets for novice users and those ancillary to image analysis. Second, a custom and sophisticated pipeline with extremely high spatial fidelity that additionally incorporates both transcriptomics and proteomics data highlights both the versatility of the platform and easy compatibility with common open-source analysis tools.

Ion World 2022: The Virtual Event That Gets Real About NGS
June 22-23, 2022 | 12:00 p.m. EDT

Please join for Ion World 2022, where scientists and professionals from around the world share how they are advancing research in a broad range of application areas – Oncology, Infectious Disease, Reproductive Health, Inherited Disease and basic research using the Ion Torrent™ sequencing systems, the GeneStudio™ and Genexus™ systems. Ion World 2022 will feature over 15 speakers, also be sure to view the content available on demand at your convenience.

Best Practices: How to Automate Flow Cytometry for Screening and High Throughput Applications
June 23, 2022 | 11:00 p.m. EDT

This webinar will discuss how flow cytometry instruments built with automation in mind can help actualize the high-throughput potential of an instrument as analysis demands increase further. It will also explore how flow cytometers ready for robotic integration and with automation features can simplify operations, save time, and improve lab performance.

If you’re thinking about how automation could accelerate your research, join this webinar that will provide a strong foundation of best practices to set you up for automation success.

Characterization and Sequence Mapping of mRNA Therapeutics Using Mass Spectrometry
June 23, 2022 | 11:00 a.m. EDT

There is currently significant demand for the development of new and improved analytical methods for the characterization of mRNA therapeutics. The ability to rapidly identify, characterize and sequence map large mRNA therapeutics with high sequence coverage provides important information for identity testing, sequence validation and impurity analysis.

This webinar will discuss how the development of an automated, high-throughput workflow for the rapid characterization and direct sequence mapping of large RNA and mRNA molecules enables routine comprehensive sequence coverage from a single analysis while overcoming challenges associated with digestion, oligonucleotide separation and identification.

Akoya Biosciences: PhenoCycler™- Fusion Roadshow Toronto
June 23, 2022 | 2:00 p.m. EDT

Akoya, a world leader in spatial biology, is organizing the PhenoCycler World Tour in person event in Toronto.

During this event you can learn how the new Fusion can scale your discoveries through increased speed and throughput, hear from spatial biology experts as they discuss their visions and future aspirations to advance the field, and reconnect with peers over drinks and hors d’oeuvres.

Organoids for Airway and Alveolar Disease Modeling
June 27, 2022 | 11:00 a.m. EDT

This webinar will discuss the development of respiratory airway and alveolar organoids derived from human iPSCs and how these are used in modeling respiratory diseases such as cystic fibrosis. In addition, airway organoid models can be used for testing the therapeutic efficacy of candidate drugs for respiratory diseases. Regenerated airway and alveolar cells derived from human iPSCs express proteins that match human respiratory cell biomarkers and play an important role in pathogenesis, such as ACE2 receptor protein in SARS-CoV-2 infections. Our panelists will discuss scaling, standardization, gene editing, co-culture, and imaging of these organoid disease models, as important resources for pharmacologic, toxicologic, functional, and efficacy studies in respiratory drug development initiatives.

Single Cell Fixed RNA Profiling Sample Prep
June 28, 2022 | 11:00 a.m. EDT

The CRISPR-Cas9 system provides researchers a powerful tool for manipulation of cells to create disease models, reporter cell lines, cell therapy tools, and approaches for novel pathway discoveries. Yet, the steps involved in designing reagents, assessing efficiency of edits, and characterizing cell populations can be time-consuming and laborious. The Invitrogen™ TrueDesign™ Genome Editor software is a one-stop design tool for optimizing CRISPR guide RNAs and donor designs for precise genome editing. The growing lineup of Invitrogen™ TrueTag™ DNA Donor kits offer a full suite of options for successful gene tagging or knockout cell line creation in significantly less time than traditional workflows.

Innovations in Mass Spectrometry
June 28, 2022 | 11:00 a.m. EDT

Join this webinar to hear about the most recent and innovative developments in the world of mass spectrometry and how they are helping to drive science forward.

Mass spectrometry has become an indispensable tool for many industries, from pharmaceutical and drug development to food and environmental analysis. Constant development and improvements are helping to make the technologies more accessible, easier to use, more sensitive and faster whilst reducing their footprint both physically and environmentally.

Mastering Basic Techniques for Cancer Cell Culture
June 29, 2022 | 12:00 p.m. SGT

The disease of cancer is inherently complex, and studying cancer in the research laboratory requires specialized skills and tools. Gibco Galaxy Tour Webinar connects you to our Gibco experts who will share their knowledge and experience to help you master modelling the complexities of cancer in your research. We will enhance your laboratory skills by providing an overview of the hallmarks of cancer and helping you to select the right cell models, media, reagents, and tools to model those features in vitro.

The Landscape of Cancer Research 2022
June 29, 2022 | 11:00 a.m. EDT

Returning for a second year, this online event will provide researchers with a unique opportunity to hear about the advances taking place within cancer research. It will bring together a broad cross-section of experts to share their work in areas such as omics, immunology, drug discovery and cell science.

Insights into Structure, Dynamics, and Function of Endocytic Vesicles on the STELLARIS Confocal Platform
June 29, 2022 | 10:00 p.m. EDT

This webinar will show how STELLARIS provides an integral access to these different layers of information from dynamic, structural, and mechanistic insights into vesicle trafficking. The endocytic vesicles shuttle materials between different cellular compartments, with the extracellular space, and the endocytic pathway is vital to almost all aspects of cell life and disease. This pathway is of particular interest in host-pathogen studies as many viruses and bacteria can exploit it as an cell entry point. The webinar will discuss the main aspects of our confocal platform that enable excellent image quality, spatiotemporal resolution even at the nanoscopy level, and functional information.

How to scale to comprehensive genomic profiling while reducing cost, time, and labor
June 29, 2022 | 11:00 p.m. EDT

Scaling to comprehensive genomic profiling (CGP) introduces unique challenges, such as handling exponentially more variants, encountering more incidental germline findings, and accurately interpreting co-occurring variants that can impact prognosis, diagnosis, and treatment responses. This webinar will present a workflow-agnostic, informatics software solution that enables clinical diagnostic labs to scale from 50 to 500 genes while reducing cost, time, and labor.

OLINK: Putting Proteomics at the Heart of Your Multiomics
On Demand

In this webinar, two speakers will present diverse case studies to illustrate how multi-omics is being used to deepen our understanding of human biology.

Dr. Karl Smith Byrne will present the results of a large Mendelian Randomization study that has identified several novel etiological markers of cancer risk from the blood proteome. He will talk about how these protein biomarkers could be used to advance our understanding of cancer pathways and help identify novel drug targets.

Dr. Erin Macdonald-Dunlop will discuss the comparison of multi-omics models that track how we age and how well these biological omics of aging clocks indicate current health status. She will also highlight how these models can predict the risk of developing age-related diseases in the future.

Agilent BioTek Lionheart Technology: Driving Physiological Relevance in Early Drug Discovery
On demand

Agilent BioTek’s innovative Lionheart platform offers automated microscopy with 1.25x to 100x magnification (including 60 and 100x oil immersion), with fluorescence, brightfield, high-contrast brightfield, color brightfield, and phase-contrast channels driving application diversity. Live cell assays illustrate the phenotypic and morphological changes that occur, and microscopy further allows one to visualize proposed mechanisms at work. This combination of widefield imaging capabilities within a single instrument drives greater workflow efficiency and productivity than ever before.

Spatial Phenotyping of Tumor Microenvironment for Characterizing Tertiary Lymphoid Structures
On Demand

Advances in cancer immunotherapy suggest that tumor-infiltrating lymphocytes (TILs) are critical for the elimination of tumor cells and maintenance of effective immunosurveillance. Spatial phenotyping is a key element of these studies because identifying and characterizing the crosstalk between TIL sheltered in on tertiary lymphoid structures (TLS) is critical to understanding how anti-tumor immunity is generated in the tumor microenvironment (TME) to drive patient survival.

In this GEN webinar, the distinguished presenter, Dr. Karen Willard-Gallo, will share her study findings on TLS, T follicular helper cells (Tfh), and B cells in human breast cancer.

Agilent BioTek Cytation/BioSpa Technology for Quantitative Live-Cell Imaging Assays
On Demand

BioTek’s Cytation 5/BioSpa 8 is an integrated automated imaging system for live cell functional assays. It is supported by Gen5™ software to perform automated image capture, processing, and  quantitative imaging analysis.

The BioLab/BioTek co- hosted webinar discusses the capabilities of Cytation/BioSpa  imaging platform for quantification of various phenotypic assays including apoptosis, cell proliferation, cytotoxicity, cell cycle, cell migration, 3D cellular models etc., that enable the biopharmaceutical and cancer researchers to develop innovative, cutting-edge cell therapies and immuno-oncology approaches to treating cancer.

Effective Nuclei Isolation From Tissue for Single-Nucleus Sequencing
On Demand

Single-cell sequencing applications have accelerated breakthroughs in life sciences, leading to significant impacts for disease treatments.

Single-nuclei RNA-sequencing (snRNA-Seq) has been shown to be an acceptable substitute for scRNA-Seq in many applications. However, current protocols for isolating nuclei from complex tissues typically include labor-intensive, manual methods for mechanical disaggregation of the tissue and debris removal. These methods are not scalable to run multiple samples in parallel.

Learn how to generate high-quality and high-yield single-nucleus suspensions from a wide range of fresh and frozen tissues – otherwise seen as unsuitable samples – and achieve new heights in your genomic analysis. In this webinar, we present a standardized workflow solution, including easy and automated nuclei extraction and isolation for reproducible single-nucleus sequencing analysis.

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