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BioLab

BioLab at OICR is a shared instrumentation division that provides advanced state-of-the-art equipment, tools and technical know-how to support lab research activities for OICR researchers and collaborators.

The mission of BioLab is to educate, enable and inspire OICR researchers and collaborators to achieve their research objectives and professional development goals by providing instrument access, knowledge transfer and continued education on advanced cancer technologies and innovations.

BioLab provides its educational offerings through three main intersecting activities:

  • BioLab provides access to advanced technology and leading-edge instrumentation, tools and supports training that brings new knowledge and skills.
  • To maximize the exposure to current knowledge in transdisciplinary cancer research, BioLab offers participation in the networks of science communication such as online webinars and virtual events.
  • BioLab fosters educational collaboration between researchers and technology providers by sharing knowledge, resources and expertise for faster and more effective communication and learning.

BioLab Hub

To better assist OICR researchers during the COVID-19 pandemic, BioLab has extended its educational offerings by launching the BioLab Hub initiative.

BioLab Hub posts bi-weekly selections of free webinars and virtual events (symposiums, conferences, and summits) on new technologies, instrumentation, applications and innovations related to cancer research.

Upcoming Events

Fixed or Frozen Sample Preparation: Best Practices, New Capabilities And Increased Flexibility For Single Cell And Spatial Analysis
Nov 29, 2022 I 2:00 p.m. EDT

The vast complexities of biology require approaches that build a complete picture from single cells to tissues and beyond. Studies often require diverse tissue types from either fresh, frozen or fixed samples. 

This seminar will discuss sample preparation best practices for Chromium Single Cell and Visium Spatial analysis from 10x Genomics: the newest options and techniques, best practices, and new solutions.

Topics to be covered:

  • Chromium Single Cell Fixed RNA Profiling: Enable storage for transport and/or batched runs in single cell experiments with PFA fixation, without compromising sample integrity or data quality. Streamline single cell workflows, improve sample accessibility, and overcome logistical challenges by preserving fragile biology at the point of collection
  • Single nuclei profiling: Ensure reliable results from multiple tissue types with the Chromium Nuclei Isolation Kit, optimized for use with Chromium gene expression and chromatin accessibility assays
  • New protocols for for Fixed and FFPE samples: Perform Visium Spatial and Single Cell from the same FFPE block
  • Visium Spatial transcriptomics with Visium Cytassist: Updated workflow and QC recommendations for whole transcriptome mapping optimized for highly sensitive and specific gene capture from FFPE samples from both archived and stained sections.
Proteomics ONLINE: Leveraging a new era of protein structure prediction to advance proteomic-driven drug discovery
Nov 29, 2022 I 10:00 a.m. EDT

Learn how the latest developments in structural proteomics are increasing our understanding of protein dynamics, interactions, and cross-linking and how this is improving drug target discovery. 

Exploring Long- and Short-Read Sequencing
Nov 30, 2022 I 10:00 a.m. EDT

 The changing sequencing landscape is a minefield with new technologies, new analysis approaches and new players hitting the market. With the decreasing cost of sequencing (welcome to the $100 genome), and the legal changes to the short-read market, how can we stay ahead of the game? This webinar will help you answer questions, such as: When is long-read sequencing best? How long is long enough? How can we leverage both technologies to better understand the human genome?

Talks: 

  • Population-scale assessment of structural variation in frontotemporal dementia, Speaker: Wouter De Coster, Research Associate, University of Antwerp & VIB
  • The molecular screening and therapeutic study: A national precision oncology program, Speaker: David Thomas, Head of Genomic Cancer Medicine, Garvan Institute of Medical Research
  • Long-read transcriptome sequencing reveals isoform diversity across human neurodevelopment, Speaker: Rosemary Bamford, Research Fellow, University of Exeter
A Fast, High-Throughput, All-in-One Pharmacogenomics Workflow That Targets Actionable SNPs And CNVs and Supports Customization
Nov 30, 2022 I 12:00 p.m. EDT

Researching the effectiveness of drugs for individuals and stratified groups can be accomplished through examination of inherited genetic traits. This pharmacogenomics approach enables the analysis of a broad range of data in an effort to gather all relevant information.

The Advanta™ Pharmacogenomics Assay provides an efficient and cost-effective solution that allows you to process SNPs and CNVs from up to 96 samples in a single workflow using extraction-free buccal swabs. With a simple load-and-run protocol and automated reagent mixing using nanoliter volumes, microfluidics technology significantly minimizes pipetting steps, hands-on time and reagent consumption.

Proteomics ONLINE: Using advanced proteomic techniques to uncover novel biomarkers for disease
Dec 6, 2022 I 10:00 a.m. EDT

Abstract: Discover how the latest technologies allow for the comprehensive identification and quantification of disease-relevant biomarkers, and ultimately what this means for patients

Talks: 

  • Using Advanced Proteomics for Clinical Biomarker Discovery and Quantification,  Speaker:  Axel Ducret, Expert Scientist and Group Lead, Roche
  • Olink Proximity Extension Assay: A Novel Affinity Technique for Disease Biomarker Discovery, Speaker: Dale Yuzuki, Director, Olink Proteomics
  • Rationalising Anti-Cancer Drug Responses Using Proteomics and Machine Learning: Towards Next Generation Precision Medicine, Speaker: Pedro Cutillas, Professor of Cell Signalling and Proteomics, Barts Cancer Institute London 

Using Targeted Proteomics for Multi-Analyte Detection in Clinically Relevant Samples, Speaker: Benedetta Lombardi, Senior Scientist, AstraZeneca 

ChipCytometry™ Multiplexing: Practical, Approachable, Spatial Biology
Dec 6, 2022 I 12:00 p.m. EDT

Spatial biology: high parameter spatial analysis of intact specimens, including both image-based and sequencing-based omics methods, have rapidly gained popularity. Developers strive to enable researchers to collect high parameter datasets. Researchers wish to employ these methods to further understand disease. 

This webinar will introduce the ChipCytometry™ technology and its CellScape™ instrument as a practical, approachable method for incorporating multiplexed spatial biology into an existing research program.

Whole-Well Brightfield Cell Counting with the Latest in Microplate Imaging Technology
Dec 7, 2022 I 11:00 p.m. EDT

Scientists who use live cell imaging to count adherent cells cultured in microplate wells must label the cells or cellular substructures with fluorescent dyes. However, these labeling processes are invasive and typically toxic to cells, causing abnormal cellular behavior and compromising scientific findings. Label-free imaging and analysis of cells using the brightfield imaging channel is a non-invasive, non-toxic alternative to fluorescent microscopy, but is challenging using conventional microscopes and automated imaging systems.

This  webinar will discuss how this technology enables rapid, easy-to-use cell counting of adherent cells in microplate wells, creating new opportunities for researchers to conduct live cell experiments and non-invasive cell analysis.

Exploring the Changing Sequencing Landscape in 2022 and Beyond
Dec 7, 2022 I 10:00 a.m. EDT

The changing sequencing landscape is a minefield with new technologies, new analysis approaches and new players hitting the market. With the decreasing cost of sequencing (welcome to the $100 genome), and the legal changes to the short-read market, how can we stay ahead of the game?

Gibco Cell Culture Heroes: 60th Anniversary Edition
Dec 7, 2022 I 12:00p.m. EDT

Join this exciting live panel webinar, as Gibco celebrates the 60th anniversary of Gibco Cell Culture. The panelists have shared pivotal moments in their research careers and share details of their research journey from various perspectives with one core commonality that has helped them along the way, cell culture. You will also learn what they predict the next 60 years of cell culture will look like and its overall impact on research outcomes.

Building Bridges to Equitable Genetic Care
Dec 8, 2022 I 11:00 a.m. EDT

Genetic Medicine has moved to the forefront of health care throughout the world, yet access to quality genetic care is unequally distributed across the country. Most genetic centers are based in large academic institutions leaving rural communities underserved, creating inequalities to access. A genetic diagnosis is increasingly becoming key to patient care, in some cases with life-altering or life saving effects. Providing families with genetic care close to home poses extraordinary challenges in Montana; the 4th largest state with 76% of its population living in rural and frontier areas.

In this Inside Precision Medicine Webinar you will learn about the innovative model at Shodair Children’s Hospital. The Genetics Department at Shodair Children’s Hospital stands unique in the United States as a provider of comprehensive clinical and laboratory genetic services to rural, frontier and largely underserved regions.

Using E. coli To Identify Stability Liabilities in Therapeutic and Disease-Causing Proteins
Dec 8, 2022 I 11:00 a.m. EDT

Many years have passed since recombinant human insulin, the first medicine made via recombinant DNA technology, was approved by the FDA. The continuous rise in the approval of protein therapeutics demonstrates the potential that biopharmaceuticals have to become the medicines of the future.

This exclusive Technology Networks webinar focuses on the most recent and innovative strategies for therapeutic antibody development and production. The speaker, Professor Brockwell, will describe the development and use of a new assay to investigate important proteins in disease screening and the biopharmaceutical industry.

Proteomics: Pushing Towards Single-Cell Resolution
Dec 12, 2022 I 11:00 a.m. EDT

Single-cell techniques are popular for obtaining genetic information, which catalyzes increased interest in genomics and transcriptomics. Various physical and technical challenges have made it difficult for proteomics to follow suit, until now. Single-cell proteomics techniques are becoming mainstream. 

In this webinar brought to you by The Scientist’s Creative Services Team, Nikolai Slavov and Abhishek Garg will discuss single-cell proteomic approaches, integrating this data with data from other -omics studies, and what single-cell proteomics reveals about biology, health, and disease.

Novel methods for the development of stem cell-derived 2D and 3D models
Dec 12, 2022 I 11:00 a.m.

Stem cells are an invaluable tool for generating multiple cell types from individual patients. However, the workflows associated with growing, differentiating and CRISPR gene editing induced pluripotent stem cells (iPSCs) in 2D and 3D culture are inefficient, low-throughput, costly, time-consuming and manually labor-intensive.

In this webinar, STEMCELL’s experts will describe how to culture and differentiate choroid plexus organoids derived from hPSCs, and how they can be applied to answer specific research questions.

Proteomics ONLINE: Drugging the “Undruggable” Proteome
Dec 13, 2022 I 10:00 a.m.

Learn how the latest advances in proteomics are allowing drug developers to target more of the proteome, therefore introducing novel opportunities for drug discovery.  

Talks: 

  • Using Innovative Methods to Unlock the Undruggable Proteome in the Biopharmaceutical Industry, Speaker:  Ashok Dongre, Director and Head of Proteomics, Bristol Myers Squibb 
  • Deep Visual Proteomics: An Opportunity to Identify Novel Targets for Drugs and Diagnostics, Speaker: Andreas Mund, Associate Professor, Novo Nordisk Center for Protein Research 
The Human Data Era
On Demand

Join this webinar event to explore The Human Data Era, a special edition podcast series produced by The Scientist’s Creative Services team and brought to you by Amgen, a pioneer in the science of using living cells to make biologic medicines.

By studying human genetics, scientists discovered mechanisms that, when defective, cause disease. While this type of data is powerful, additional information can provide more insight on the human condition. Researchers and clinicians can now go beyond genetics, combining proteomics, metabolomics, transcriptomics, and environmental factors into a broad category of human data. Scientists and clinicians are making an important transition to incorporate this wealth of information into drug research and development.

Cell and Gene Therapy: From Concept to Clinical Use
On Demand

A major concern for those intending to bring cell and gene therapy products to market is the manufacturing needs as the product moves from small- to large-scale.

In order to keep up with these changes, focus must be given to the eventual scale of production and shift from R&D to GMP compliance.

This webinar will provide an introduction to the regulatory framework for cell and gene therapies and highlight the importance of chemistry, manufacturing and controls.

Single-Cell Spatial Transcriptomics with Cleavable Fluorescent Probes
On Demand

Scientists use in situ hybridization (ISH) to reveal the location of specific nucleic acid sequences within cells, which is a crucial step for understanding gene organization, regulation, and function. In situ hybridization can preserve spatial information, which avoids the masking of cellular heterogeneity that comes with bulk analysis. 

In this Technique Talk, Jia Guo will explore the fundamentals of ISH and the development and use of novel in situ hybridization technology to investigate complex biological systems.

Forge a Successful CRISPR Therapeutic Path With High-Quality sgRNA
On Demand

The rapid increase in CRISPR-mediated cell and gene therapies in clinical trials over the past few years is a testimony to the promising future of next-generation medicine.

While improved technological prowess empowers the development of more CRISPR-edited therapies, supply-chain and manufacturing hurdles still pose significant barriers to clinical and commercialization timelines.

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