Dr. Brad Wouters
Dr. Brad Wouters’ lab has identified new signalling pathways that influence how tumours respond to environments with reduced oxygenation. Unlike most tissue, tumour cells can survive and thrive in environments starved of oxygen. Characterized by extreme differences in nutrient supply, pH, and oxygenation, these environments promote tumour malignancy and prevent effective treatment for patients. Using high-throughput approaches the lab is defining the molecular basis of these signalling pathways and establishing their importance for future cancer therapies.
- Senior Investigator, OICR;
- Executive Vice-President, Science and Research at University Health Network;
- Professor, Department of Radiation Oncology, University of Toronto;
- Senior Scientist and Director, Hypoxia and Microenvironment Program, Ontario Cancer Institute.
Magagnin MG, VandenBeucken T, Sergeant K, Lambin P, Koritzinsky M, Devreese B and Wouters BG.
The mTOR target 4E-BP1 contributes to differential protein expression during normoxia and hypoxia through changes in mRNA translation efficiency.
Koritzinsky M, Rouschop KM, van den Beucken T, Magagnin MG, Savelkouls K, Lambin P, Wouters BG.
Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia.
Radiother Oncol. 2007;83(3):353-61.
Chiu RK, Brun J, Ramaekers C, Theys J, Weng L, Lambin P, Gray DA, and Wouters BG.
Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations.
PLOS Genetics. 2006;2:e116.
Koritzinsky M, Magagnin MG, van den Beucken T, Seigneuric R, Savelkouls K, Dostie J, Pyronnet S, Kaufman RJ, Weppler SA, Voncken JW, Lambin P, Koumenis C, Sonenberg N, and Wouters BG.
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control.
EMBO Journal. 2006;25:1114-1125.
Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Ron D, Wouters BG.
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.
Mol Cell Biol. 2002;(21):7405-16.
Previous experience and education
- Full Professor and Head Scientist, Maastricht Radiation Oncology Laboratory (Maastro Lab) azM/University of Maastricht/GROW Research Institute, GROW Research Institute;
- Associate Professor and Head Scientist, Maastricht Radiation Oncology Laboratory (Maastro Lab ) azM/University of Maastricht, GROW Research Institute;
- Assistant Professor, Department of Radiology, Faculty of Medicine, University of Ottawa;
- Associate Research Scientist, Research Institute, Ottawa General Hospital;
- Career Scientist, Centre for Cancer Therapeutics, The Ottawa Hospital Cancer Centre (TOHCC);
- Postdoctoral Fellow, School of Medicine, Department of Radiation Oncology, Stanford University;
- PhD in Physics, Department of Medical Biophysics, Supervisor: Dr. Lloyd D. Skarsgard, University of British Columbia.
Opportunities to collaborate and contact
Dr. Wouters welcomes collaboration. Contact Dr. Wouters at firstname.lastname@example.org for more information.
Visit OICR’s Collaborative Research Resources directory for more opportunities to collaborate with OICR researchers.