Dr. Mathieu Lupien
Dr. Mathieu Lupien
Dr. Mathieu Lupien
Mid-Career Investigator


Mid-Career Investigator

Dr. Lupien works to characterize and understand the role of noncoding regulatory elements as targets of genetic and epigenetic changes in oncogenesis. Dr. Mathieu Lupien is a Senior scientist at the Princess Margaret Cancer Centre and holds a cross-appointment with OICR.

Lupien’s research highlights the need to characterize the epigenetic basis of cancer to understand the role of the noncoding cancer genome and identify new therapeutic opportunities and complementary markers of response.

Lupien is recognized for three seminal discoveries:

  1. Epigenetic modifications on histones can discriminate cell-type-specific-noncoding gene regulatory elements in normal and cancer cells.
  2. Epigenetic alterations at gene regulatory elements underlie cancer initiation and progression.
  3. Noncoding genetic alterations promoting cancer development preferentially target gene regulatory elements.

Lupien’s research is centered on identifying the epigenetic changes in cancer cells and to reveal their underlying molecular biology. The ultimate goal is to develop new and improved strategies to hinder cancer development.

Experience & Education
  • Scientist, The Princess Margaret Cancer Centre
  • Assistant Professor, Department of Medical Biophysics, University of Toronto
  • Director, Quantitative Epigenomics Laboratory, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School
  • Assistant Professor, Department of Genetics, Dartmouth Medical School, Norris Cotton Cancer Center
Current Affiliations
  • Mid-Career Investigator, OICR
  • Associate Professor, Department of Medical Biophysics, University of Toronto
  • Senior scientist, Princess Margaret Cancer Centre
Select Publications

See Dr. Lupien’s recent publications on PubMed or on Google Scholar.

Research Areas
Disease Areas
  • Till and McCulloch Discovery of the Year (Basic) Award, 2012, 2017
  • Rising Star in Prostate Cancer Research Award, 2014
  • Canadian Institutes of Health Research, New Investigator Salary Award, 2014
  • OICR Investigator Level I Award, 2012
Opportunities to Collaborate

To collaborate with Dr. Lupien, please contact him directly.

Visit OICR’s Collaborative Research Resources directory for more opportunities to collaborate with OICR researchers.

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