Dr. Lillian Siu
Dr. Lillian Siu
Dr. Lillian Siu
Co-Principal Investigator, OCTANE


Co-Principal Investigator, OCTANE

Dr. Siu is Co-Principal Investigator of the Ontario-wide Cancer TArgeted Nucleic acid Evaluation (OCTANE) study. Dr. Lillian Siu is a senior medical oncologist at the Princess Margaret Cancer Centre and a Professor of Medicine at the University of Toronto. She is the Co-Principal Investigator of the OICR-supported Ontario-wide Cancer TArgeted Nucleic Acid Evaluation (OCTANE) study.

Dr. Siu is the Director of the Phase I Program and Co-Director of the Bras and Family Drug Development Program at the Princess Margaret Cancer Centre, holds the BMO Chair in Precision Cancer Genomics, and is the clinical lead for the Tumor Immunotherapy Program at the Princess Margaret Cancer Centre. Dr. Siu served on the Board of Directors for the American Society of Clinical Oncology (ASCO) for a four-year term (2012-2016). She also served as a member of the Nomination Committee for the American Association for Cancer Research (AACR) (2014-2016). She currently serves on the AACR Board of Directors for a three-year term (2017-2020).

Dr. Siu’s major research focus is in the area of new anticancer drug development, particularly with respect to phase I trials and head and neck malignancies. In addition to her active research in early phase clinical trials, she has been leading genomics initiatives and immuno-oncology trials at the Princess Margaret Cancer Centre.

Experience & Education
  • FRCPC, University of Toronto
  • MD, University of Toronto
Current Affiliations
  • Co-Principal Investigator, Ontario-wide Cancer TArgeted Nucleic Acid Evaluation (OCTANE) study
  • Senior Staff Medical Oncologist, Princess Margaret Cancer centre
  • Professor of Medicine, University of Toronto
  • Clinical Lead, Tumour Immunotherapy Program, Princess Margaret Cancer Centre
  • Executive Director, Cancer Genomics Program, Princess Margaret Cancer Centre
  • Director of Phase I Program, Princess Margaret Hospital, University Health Network
Select Publications

See Dr. Siu’s recent publications on PubMed or on Google Scholar.

Research Areas
Disease Areas
Head and Neck
  • University of Toronto, Department of Medicine, Michael Hutcheon Mentor Award, 2017-2018
  • University of Toronto, Eaton Scholar Researcher of the Year, 2016
  • University Health Network, BMO Financial Group Chair in Precision Genomics, 2016-2017
  • University of Toronto, Faculty of Medicine, Division of Medical Oncology, Research award, 2015
  • University of Toronto, Wightman-Berris Award for Individual Teaching Excellence, 2013-2014
  • University of Toronto, Division of Medical Oncology, Teaching Award, 2011
  • National Cancer Institute, Michaele C. Christian Oncology Development Award, 2010
  • Cancer Care Ontario, Tier 1 Research Chair in Experimental Therapeutics, 2009
  • Princess Margaret Cancer Centre, Medical Oncology Residency Program Teaching Award, 2003
  • University of Toronto, Wightman-Berris Award for Teaching Excellence, 2003
Opportunities to Collaborate

To collaborate with Dr. Siu, please contact her directly.

Visit OICR’s Collaborative Research Resources directory for more opportunities to collaborate with OICR researchers.