Dr. Hartland Jackson
The coordinated activity of many individual cells is necessary for the function of healthy tissues but can also drive cancer progression. Dr. Jackson’s research program investigates the locations and relationships between different cell types, their mechanisms of communication, and their use as high-dimension pathology biomarkers of disease in clinical samples. He aims to understand the formation and evolution of tissues and tumours as multi-cell systems.
Dr. Jackson is a leader in imaging mass cytometry and is the most experienced user of the Hyperion Imaging System worldwide. He developed the histoCAT computational toolbox for interactively investigating highly multiplex imaging mass cytometry data and has applied these methods to quantify the cellular architecture of breast cancer. He is now extending this approach to other cancers and complementary mouse model systems in order to identify and target multi-cellular mechanisms of cancer progression and therapeutic resistance.
Dr. Jackson is an Investigator at Sinai Health’s Lunenfeld-Tanenbaum Research Institute.
- Investigator I, OICR
- Investigator, Lunenfeld-Tanenbaum Research Institute, Sinai Health
- Single cell systems pathology
- Imaging mass cytometry
- Quantitative digital pathology
- Systems biology
- Breast cancer
- Tumour heterogeneity
- Tumour microenvironment
- Ali HR*, Jackson HW*, Zanotelli VRT, …, Bodenmiller B.Imaging mass cytometry and multiplatform genomics define the phenogenomic landscape of breast cancer. Nature Cancer. 2020; 1:163-175.
- Jackson HW*, Fischer JR*, Zanotelli VRT…, Bodenmiller B. The Single Cell Pathology Landscape of Breast Cancer. Nature. 2020; 578:615–620
- Schapiro D*, Jackson HW*, Raghuraman S, …, Bodenmiller B. histoCAT: analysis of cell phenotypes and interactions in multiplex image cytometry data. Nature Methods. 2017;14(9):873-876.
- Jackson HW, Defamie V, Waterhouse PW, Khokha R. TIMPs: Versatile Extracellular Regulators in Cancer. Nature Reviews Cancer. 2017; 17:38-53.
- Jackson HW, Waterhouse P, Sinha H, …, Khokha R. Expansion of stem cells counteracts age-related mammary regression in compound Timp1/Timp3 null mice. Nature Cell Biology. 2015; 17(3):217-27.
*Authors contributed equally.
- Cancer Research Society Scholarship for the Next Generation of Scientists, 2018
- Canadian Institute of Health Research Post-Doctoral Fellowship, 2016
- SystemsX Transitional Post-Doctoral Fellowship, 2015
- European Molecular Biology Organization Long-Term Fellowship, 2015
- Postdoctoral Fellow, University of Zurich
- PhD, Princess Margaret Cancer Centre, University of Toronto
Opportunities to collaborate
To collaborate with Dr. Jackson, please contact him directly.
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Dr. Hartland Jackson