Dr. Kristin Hope

Investigator I

Dr. Kristin Hope’s research program is focused on dissecting the molecular regulation of normal and malignant hematopoietic stem cell self-renewal. She aims to identify the underlying processes that lead to the transformation of healthy cells into leukemic cells and contribute to the progression of the disease.

Maintenance of a healthy blood system is dependent on a strict balance between the capacity of the hematopoietic stem cell pool to differentiate and its ability to renew itself. In contrast, to drive leukemic growth, leukemic stem cells are thought to function by exploiting this normally exquisitely regulated self-renewal machinery. Hope’s work focuses on understanding the molecular control of stemness at the level of RNA processing and regulation where RNA binding proteins play an integral role. In particular her research is exploring the premise that RNA binding protein-driven post-transcriptional control is a critical mode by which self-renewal and transformation are regulated in hematopoiesis. With this work Hope and her team aim to identify novel stem cell regulators that could inform the design of enhanced hematopoietic stem cell-based regenerative therapies on one hand and leukemic stem cell-targeted anti-leukemic therapies on the other.

Current affiliations

  • Investigator I, OICR;
  • Assistant Professor, Biochemistry and Biomedical Sciences, McMaster University, Hamilton;
  • Principal Investigator, McMaster Stem Cell and Cancer Research Institute.

Research interests

  • RNA binding proteins.
  • Stem cell function.
  • Proteomics.
  • CLIP-seq.

Select publications

Rentas S, Holzapfel N, Belew M, Pratt G, Voisin V, Bader G, Wilhelm B, Yeo G, Hope KJ. (2016).
Musashi-2 Attenuates AHR Signaling to Expand Human Hematopoietic Stem Cells.
Nature, 532(7600): 508-11.


Hereault O*, Hope KJ*, Deneault E, Mayotte N, Chagraoui J, Whilhelm BT, Cellot S, Sauvageau M, Andrade-Navarro MA, and Sauvageau G*. (2012).
A role for GPx3 in activity of normal and leukemia stem cells.
Journal of Experimental Medicine. 209(5):895-901.


Hope KJ* and Bhatia M*. (2011).
Clonal interrogation of stem cells.
Nature Methods. 8(4 Suppl):S36-40.


Hope KJ, Cellot S, Ting S, MacRae T, Mayotte N, Iscove NN, Sauvageau G
An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity
Cell Stem Cell. 2010;7(1):101-113


Jin L*, Hope KJ*, Zhai Q, Smadja-joffe F, Dick JE
Targeting of CD44 eradicates human acute myeloid leukemia stem cells due to abrogation of stem cell trafficking and induction of differentiation
Nature Medicine. 2006;12(10):1167-1174

*authors made equal contribution.

Awards

  • MRI Early Researcher Award;
  • OICR New Investigator Award;
  • Cole Foundation Postdoctoral Fellowship;
  • CIHR Post-doctoral Research Fellowship;
  • NCIC Post PhD Research Fellowship (Declined);
  • FRSQ Post-doctoral Training Award (Declined);
  • CIHR Doctoral Research Fellowship;
  • Ontario Graduate Scholarship.

Previous experience and education

  • Postdoctoral Fellow, Laboratory of Dr. Guy Sauvageau, Université de Montréal;
  • PhD, Molecular and Medical Genetics, University of Toronto;
  • PhD Graduate Student, Laboratory of Dr. John Dick, University of Toronto.

Opportunities to collaborate

The Hope Lab is always looking to explore fruitful new avenues to understanding stem cell function through novel collaborations. The lab offers expertise in wide a range of methodologies and approaches, including primary human cell culture, lentivirus infection, xenotransplantation, multiparameter high throughput flow cytometry and CLIP-seq.

Related links

Contact

kristin@mcmaster.ca