Dr. Lincoln Stein
Head, Adaptive Oncology
Dr. Lincoln Stein focuses on using network and pathway-based analysis to identify common mechanisms in multiple cancer types and to devise prognostic and predictive signatures to aid in patient management. In addition, his group works on problems relating to the genome structure and function of the nematode Caenorhabditis elegans, a model organism that has yielded many insights into cancer.
- Head, Adaptive Oncology, OICR
- Chair of the International Cancer Genome Consortium Executive Committee, International Scientific Steering Committee and Data Coordination and Management Committee
- Member of the Pan Cancer Analysis of Whole Genomes (PCAWG) Steering Committee
- Member of the ICGCmed Scientific Planning Committee Data Coordination and Management Committee
- Professor, Department of Molecular Genomics, University of Toronto
- Professor, Cold Spring Harbor, New York
- Shlush LI, Zandi S, Mitchell A, …, Stein LD, …, Dick JE. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature. 2014;506(7488):328-33.
- Gonzalez-Perez A, Mustonen V, Reva B, …, Stein LD, Lopez-Bigas N; International Cancer Genome Consortium Mutation Pathways and Consequences Subgroup of the Bioinformatics Analyses Working Group. Computational approaches to identify functional genetic variants in cancer genomes. Nat Methods. 2013;10(8):723-9.
- Trinh QM, Jen FY, Zhou Z, …, Stein LD. Cloud-based uniform ChIP-Seq processing tools for modENCODE and ENCODE. BMC Genomics. 2013;14:494.
- Biankin AV, Waddell N, Kassahn KS, …, Stein LD, …, Grimmond SM. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature. 2012;491(7424):399-405.
- Gerstein MB, Lu ZJ, Van Nostrand EL, …, Stein L, Lieb JD, Waterston RH. Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science. 2010;330(6012), 1775-1787.
Dr. Stein was named one of the World’s Most Influential Scientific Minds by Thompson Reuters in 2014 and a Fellow of the International Society of Computational Biology (ISCB) in 2016.
Previous experience and education
- Interim Scientific Director, OICR
- Program Director, Informatics and Bio-computing, OICR
- Associate Professor, Cold Spring Harbor, New York
- Director Information Systems, CuraGen Corporation
- Instructor, Harvard Medical School, Dept. of Pathology, Brigham & Women’s Hospital
- Director, Informatics Core, MIT Genome Center, Whitehead Institute for Biomedical Research, MIT
- MD, Harvard Medical School
- Residency, Anatomic Pathology, Brigham & Women’s Hospital
- PhD, Cell Biology, Harvard University
Dr. Lincoln Stein