Dr. Mathieu Lupien

Investigator II

Dr. Mathieu Lupien is a Senior scientist at the Princess Margaret Cancer Centre and holds a cross-appointment with OICR.

Lupien’s research highlights the need to characterize the epigenetic basis of cancer to understand the role of the noncoding cancer genome and identify new therapeutic opportunities and complementary markers of response.

Lupien is recognized for three seminal discoveries:

  1. Epigenetic modifications on histones can discriminate cell-type-specific-noncoding gene regulatory elements in normal and cancer cells.
  2. Epigenetic alterations at gene regulatory elements underlie cancer initiation and progression.
  3. Noncoding genetic alterations promoting cancer development preferentially target gene regulatory elements.

Lupien’s research is centered on identifying the epigenetic changes in cancer cells and to reveal their underlying molecular biology. The ultimate goal is to develop new and improved strategies to hinder cancer development.

Current affiliations

  • Investigator II, OICR
  • Associate Professor, Department of Medical Biophysics, University of Toronto
  • Senior scientist, Princess Margaret Cancer Centre

Research interests

  • Epigenomics
  • Chromatin architecture
  • Genetics of cancer
  • Bioinformatics
  • Computational science
  • Transcriptional regulation
  • Breast cancer
  • Prostate cancer
  • Cancer stem cells

Select publications

See Dr. Lupien’s recent publications on PubMed or on Google Scholar.



  • Till and McCulloch Discovery of the Year (Basic) Award, 2012, 2017
  • Rising Star in Prostate Cancer Research Award, 2014
  • Canadian Institutes of Health Research, New Investigator Salary Award, 2014
  • OICR Investigator Level I Award, 2012

Previous experience

  • Scientist, The Princess Margaret Cancer Centre
  • Assistant Professor, Department of Medical Biophysics, University of Toronto
  • Director, Quantitative Epigenomics Laboratory, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School
  • Assistant Professor, Department of Genetics, Dartmouth Medical School, Norris Cotton Cancer Center

Related links

Lupien Lab website

Opportunities to collaborate

To collaborate with Dr. Lupien, please contact him directly.

Visit OICR’s Collaborative Research Resources directory for more opportunities to collaborate with OICR researchers.


Dr. Mathieu Lupien