Dr. Naoto Hirano

Clinician Scientist I

Dr. Naoto Hirano’s research program aims to devise novel anti-tumor immunotherapeutic modalities that can cure cancer. Dr. Hirano’s research team is particularly interested in understanding how the interactions between T cells and antigen-presenting cells affect priming, expansion, persistence and differentiation of T cells, as well as how this leads to the subsequent generation and maintenance of anti-tumor T cell memory.

Current affiliations

  • Clinician Scientist I, OICR;
  • Associate Director for Research, Tumour Immunotherapy Program, Princess Margaret Cancer Centre;
  • Senior Scientist, Princess Margaret Cancer Centre;
  • Professor of Medicine, Department of Immunology, University of Toronto.

Research interests

  • Cancer immunotherapy;
  • Adoptive T-cell therapy.

Select publications

Benveniste PM, Roy S, Nakatsugawa M, Chen ELY, Nguyen L, Millar DG. Ohashi PS, Hirano N, Adams EJ, Zúñiga-Pflücker JC.
Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells. 
Sci Immunol. 2018; In press.

Kagoya Y, Nakatsugawa M, Saso K, Guo T, Anczurowski M, Wang CH, Butler MO, Arrowsmith CH, Hirano N.
DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models. 
Nat Commun. 2018; 9(1):1915.

Kagoya Y, Tanaka S, Guo T, Anczurowski M, Wang CH, Saso K, Butler MO, Minden MD, Hirano N.
A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects.
Nat Med. 2018; 24(3):352-359.

Ghazarian M, Revelo XS, Nøhr MK, Luck H, Zeng K, Lei H, Tsai S, Schroer SA, Park YJ, Chng MHY, Shen L, D’Angelo JA, Horton P, Chapman WC, Brockmeier D, Woo M, Engleman EG, Adeyi O, Hirano N, Jin T, Gehring AJ, Winer S, Winer DA.
Type I Interferon Responses Drive Intrahepatic T cells to Promote Metabolic Syndrome. 
Sci Immunol. 2017; 2(10).

Yamashita Y, Anczurowski M, Nakatsugawa M, Tanaka M, Kagoya Y, Sinha A, Chamoto K, Ochi T, Guo T, Saso K, Butler MO, Minden MD, Kislinger T, Hirano N.
HLA-DP84Gly constitutively presents endogenous peptides generated by the class I antigen processing pathway. 
Nat Commun. 2017; 8:15244.

See Dr. Hirano’s recent publications on PubMed.

Previous experience and education

  • Assistant Professor of Medicine, Dana-Farber Cancer Institute, Harvard Medical School.

Related links

University Health Network Researcher Page – Dr. Naoto Hirano

Opportunities to collaborate

To collaborate with Dr. Hirano, please contact him directly.
Visit OICR’s Collaborative Research Resources directory for more opportunities to collaborate with OICR researchers.


Dr. Naoto Hirano