Dr. Anna Panchenko - Ontario Institute for Cancer Research

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Dr. Anna Panchenko

Senior Investigator

Dr. Anna Panchenko’s research group studies the genetic and epigenetic mechanisms of cancer, including the effects of mutations on protein activity, interactions and dynamics. To do so, her group designs new computational methods and algorithms that involve machine learning, molecular modeling and molecular dynamics simulations. Dr. Panchenko is particularly interested in discovering cancer-driving mutations with computational and hybrid approaches so that we can better understand – and potentially stop – the causes of cancer progression. Dr. Panchenko is a Professor in the Faculty of Health Sciences at Queen’s University and an OICR Senior Investigator. She holds a Tier I Canada Research Chair.

External Links

Panchenko Research Group website (Panchenko Lab website at Queen’s University under development)
Dr. Anna Panchenko – Queen’s University Department of Pathology and Molecular Medicine profile
Dr. Anna Panchenko – Queen’s University School of Computing profile

Experience & Education

Lead Scientist, National Center for Biotechnology Information (NCBI), National Institutes of Health (NIH)
Associate Investigator, NCBI, NIH
Staff Scientist, NCBI, NIH
Associate Professor Lecturer, Johns Hopkins University
Associate Professor Lecturer, George Washington University
Intramural Research Training Award Fellow, NCBI, NIH
Postdoctoral Fellow, University of Illinois at Urbana-Champaign
PhD, Lomonosov Moscow State University

Current Affiliations

Senior Investigator, OICR
Professor, Faculty of Health Sciences, Queen’s University
Canada Research Chair, Tier I

Select Publications

Brown AL, Li M, Goncearenco A, Panchenko AR. Finding driver mutations in cancer: Elucidating the role of background mutational processes. PLoS Comput Biol. 2019; 15(4):e1006981.
Shaytan AK, Xiao H, Armeev GA, …, Panchenko AR. Structural interpretation of DNA-protein hydroxyl-radical footprinting experiments with high resolution using HYDROID. Nat Protoc. 2018; 13(11):2535-2556.
Goncearenco A, Rager SL, Li M, …, Panchenko AR. Exploring background mutational processes to decipher cancer genetic heterogeneity. Nucleic Acids Res. 2017; 45(W1):W514-W522.
Li M, Kales SC, Ma K, …, Panchenko AR. Balancing Protein Stability and Activity in Cancer: A New Approach for Identifying Driver Mutations Affecting CBL Ubiquitin Ligase Activation. Cancer Res. 2016; 76(3):561-71.
Li M, Simonetti F, Panchenko AR. MutaBind estimates and interprets the effects of sequence variants on protein-protein interactions. Nucleic Acids Res. 2016; 44(W1):W494-501.

See Dr. Panchenko’s recent publications on PubMed or on Google Scholar.

Research Areas

Biology Cancer Origins Informatics and Data Standards

Disease Areas

All

Opportunities to Collaborate

Collaborate with us

If interested in collaborating with Dr. Panchenko, please contact her directly.

Visit OICR’s Collaborative Research Resources directory for more opportunities to collaborate with OICR researchers.

Tools

HYDROID: Hydroxyl-radical footprint gel electrophoresis image analysis and interpretation
MutaGene: Identifies and explores context-dependent mutational processes in cancer
MutaBind: Estimates effects of sequence variants on protein interactions

Editorial Boards

Associate Editor, PloS Computational Biology
Editor, Journal of Molecular Biology

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