Dr. Federico Gaiti
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Dr. Gaiti’s research focuses on providing novel insights into a central aspect of human biology – the somatic evolution of cancer cells. Cancer progression, relapse, and resistance to therapy are the result of an evolutionary optimization process in which genetic alterations generate diversity. This genetic diversity provides the critical substrate for malignant cells to evolve and adapt to the selective pressures provided by therapy. However, in addition to genetic diversity, there is a whole host of regulatory factors, like epigenetic regulation, that fuel cancer evolution. Thus, the study of cancer requires the integration of multiple dimensions at the resolution of the single cell — the fundamental unit of somatic evolution.
The goal of Dr. Gaiti’s research program is to develop and apply computational and experimental genomics and epigenomics approaches for the study of cancer evolution and analysis of single-cell multi-omics data, empowering us to simultaneously interrogate the multi-faceted axes of diversity that drive tumour evolution.
Current efforts in the lab focus on understanding:
PhD, University of Queensland, Brisbane, Australia
Postdoctoral Fellow, Weill Cornell Medical College, New York, NY, U.S.
Early-Career Investigator, Ontario Institute for Cancer Research
Scientist, Princess Margaret Cancer Centre
Assistant Professor, Department of Medical Biophysics, University of Toronto
PubMed search link for all publications: https://www.ncbi.nlm.nih.gov/myncbi/1dkybb-Qg9YQB/bibliography/public/
If you’re interested in collaborating with Dr. Gaiti, please contact him directly.
Visit OICR’s Collaborative Research Resources directory for more opportunities to collaborate with OICR researchers.