The Pai laboratory’s goal is to bring genomics and epigenetics to the clinic. We focus on childhood and adult brain cancers, and on disorders of neurodevelopmental origins.

We perform pre-clinical research analyzing patient and disease genomes to discover better biomarkers for clinical decision-making, including diagnostics, prognostics, treatment resistance, and pre-diagnostic biomarkers. We take a neurodevelopmental perspective on brain cancer, studying how molecular mechanisms of typical brain development can be dysregulated to give rise to childhood and adult brain cancers. Our projects combine approaches from genomics, bioinformatics, molecular biology, patient-derived cancer cell lines, histology, functional genomics, machine learning, and pharmacology.

To learn more, visit our lab website at: https://www.shraddhapailab.com/