Genome Informatics
Inquiries
Associate Director
Dr. Michelle Brazas
michelle.brazas@oicr.on.ca
Telephone: 416-673-8502
Mobile: 416-357-6687
Introduction
The Genome Informatics Program develops new software, databases and other necessary components to store, organize and compute over the large and complex datasets being generated by OICR’s cancer research programs. Our resources and expertise are shared with the Ontario cancer research community, with the goal of accelerating cancer research and bringing treatments to the clinic faster.
Our mission is to advance the knowledge and treatment of cancer by facilitating computation on big cancer datasets.
Our research objectives are to:
- Develop information systems that inform and apply our understanding of cancer biology to cancer clinical care
- Harmonize and disseminate large cancer-related data sets
- Train the next generation of software engineers to work on cancer-related big data problems
- Through technology, foster efficiency, communication and collaboration within and among Genome Informatics and Computational Biology, OICR and the wider community
- Articulate and translate Genome Informatics’ achievements and impacts
Opportunities to Collaborate
The Genome Informatics Program is open to and encourages research collaborations. Please contact any of the Principal Investigators or review our Collaborative Research Resources Brochure for more information.
Further opportunities to collaborate
OICR is committed to strengthening cancer research in Ontario through collaboration and broadening access to our technology infrastructure, expertise and resources. Please visit OICR’s Collaborative Research Resources directory for more opportunities to collaborate.
Programs Expertise and Capabilities
Principal investigators and directors in the Genome Informatics Program have a broad set of interests and expertise, ranging from high-performance computing and data portals, to software development for big data. While our computational activities and expertise focus on cancer, they also have broader application in genomic research. For example, Genome Informatics oversees the development of multiple websites for various Canadian and International research projects, such as the Ontario Health Study and the NCI Genomic Data Commons.
Projects
The Genome Informatics Program is involved in a wide variety of informatics projects. We play both leadership and collaborative, scientific roles in many large-scale computational initiatives, with a strong mandate to output to the scientific community open-source, open-access data, tools and resources.
Projects under the Genome Informatics Program include:
Human Cancer Models Initiative
In an international consortium that is generating novel human tumor-derived culture models, which are annotated with genomic and clinical data.
Data, Software & Tools
ICGC software stack including the Data Portal
Cancer Genome Collaboratory software stack
Genome Data Commons Portal software
Global Alliance for Genomics and Health at Dockstore
PCAWG data
over 2,400 consistently analyzed genomes corresponding to over 1,100 unique ICGC donors.
Kids First Data Resource Center software
Human Cancer Models Initiative Catalog Software
Overture collection of open-source, extendable solutions for catalog big-data genomic science.
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