Dr. Brad Wouters’ lab has identified new signalling pathways that influence how tumours respond to environments with reduced oxygenation. Unlike most tissue, tumour cells can survive and thrive in environments starved of oxygen. Characterized by extreme differences in nutrient supply, pH, and oxygenation, these environments promote tumour malignancy and prevent effective treatment for patients. Using high-throughput approaches the lab is defining the molecular basis of these signalling pathways and establishing their importance for future cancer therapies.
- Full Professor and Head Scientist, Maastricht Radiation Oncology Laboratory (Maastro Lab) azM/University of Maastricht/GROW Research Institute, GROW Research Institute
- Associate Professor and Head Scientist, Maastricht Radiation Oncology Laboratory (Maastro Lab ) azM/University of Maastricht, GROW Research Institute
- Assistant Professor, Department of Radiology, Faculty of Medicine, University of Ottawa
- Associate Research Scientist, Research Institute, Ottawa General Hospital
- Career Scientist, Centre for Cancer Therapeutics, The Ottawa Hospital Cancer Centre (TOHCC)
- Postdoctoral Fellow, School of Medicine, Department of Radiation Oncology, Stanford University
- PhD in Physics, Department of Medical Biophysics, Supervisor: Dr. Lloyd D. Skarsgard, University of British Columbia
- Senior Investigator and Board Member, OICR
- Executive Vice President, Science and Research, University Health Network
- Professor, Department of Radiation Oncology, University of Toronto
- Canada Research Chair in Hypoxia and Tumour Microenvironment
- Pagès F, Mlecnik B, Marliot F, …, Wouters BG, …, Galon J. International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study. Lancet. 2018; 391(10135):2128-2139.
- Kirsch DG, Diehn M, Kesarwala AH, …, Wouters BG, Bernhard EJ. The Future of Radiobiology. J Natl Cancer Inst. 2018; 110(4):329-340.
- Tan Q, Joshua AM, Wang M, …, Wouters BG, Allen CJ, Tannock IF. Up-regulation of autophagy is a mechanism of resistance to chemotherapy and can be inhibited by pantoprazole to increase drug sensitivity. Cancer Chemother Pharmacol. 2017; 79(5):959-969.
- Rey S, Schito L, Koritzinsky M, Wouters BG. Molecular targeting of hypoxia in radiotherapy. Adv Drug Deliv Rev. 2017; 109:45-62.
Dr. Wouters welcomes collaboration. To collaborate with Dr. Wouters, please contact him directly.
Visit OICR’s Collaborative Research Resources directory for more opportunities to collaborate with OICR researchers.