Drug Discovery Program
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Dr. David Uehling
Interim Scientific Lead, Therapeutic Innovation and Drug Discovery
duehling@oicr.on.ca
The OICR Drug Discovery Program is one of the largest programs of its kind in Canada. Our mission is to help efficiently translate discoveries made in Ontario’s labs into novel oncology therapies. The team is comprised of more than 25 researchers whose collective expertise spans the entire drug discovery process from target identification and validation to clinical candidate selection. The group has extensive drug discovery experience within pharma and biotech environments and combines the disciplines of biology, ADME/PK, analytical, medicinal and computational chemistry expertise along with state-of-the-art infrastructure necessary to successfully conduct drug discovery projects.
Please visit OICR’s Collaborative Research Resources directory for more opportunities to collaborate.
OICR enables research by providing expertise, advice and access to research services on a cost-recovery basis. Researchers can benefit from high-end technology infrastructure, world-leading research knowledge, high-quality services and support at each stage of the project development process.
OICR’s Drug Discovery program, supports the synthesis of small molecules, low to medium throughput screening, SAR analysis and hit triaging, a range of in vitro and in vivo assays to fully characterize ADME, pharmacokinetic profiles and maximum tolerated dose of candidates, including help with biochemical or cell based assay development and optimization for profiling and screening small molecule libraries.
Services available:
OICR’s Drug Discovery Team has the infrastructure and expertise to help drive small molecule drug discovery projects. We can aid in target validation, assay design and optimization, hit identification, hit triaging, hit to lead and lead optimization Structure-Activity Relationship (SAR) activities.
Additionally, a range of in vitro and in vivo experiments can be performed at OICR to fully characterize the ADME PK profile of hits, leads and candidate molecules.
OICR is making its technology infrastructure, expertise and resources available to the Ontario cancer research community through cost-sharing arrangements.
