Dr. Brad Wouters’ lab has identified new signalling pathways that influence how tumours respond to environments with reduced oxygenation. Unlike most tissue, tumour cells can survive and thrive in environments starved of oxygen. Characterized by extreme differences in nutrient supply, pH, and oxygenation, these environments promote tumour malignancy and prevent effective treatment for patients. Using high-throughput approaches the lab is defining the molecular basis of these signalling pathways and establishing their importance for future cancer therapies.