Dr. Lincoln Stein
Head, Adaptive Oncology
Dr. Lincoln Stein focuses on supporting biomedical research both in Ontario and around the world by making large and complex biological datasets findable, accessible and usable.
Prior to joining OICR in 2006, Dr. Stein played an integral role in many large-scale data initiatives at Cold Spring Harbor Laboratory and at the Massachusetts Institute of Technology (MIT) Genome Center. He led the development of the first physical clone map of the human genome, and ran the data coordinating centre and the data portal for the SNP Consortium and the HapMap Consortium. Dr. Stein has also led the creation and development of Wormbase, a community model organism database for C. elegans, and Reactome, which is now the largest open community database of biological reactions and pathways.
At OICR, Dr. Stein has led several international cancer data sharing and research initiatives, including the creation and development of the data coordination centre for the International Cancer Genome Consortium and other related projects. He continues to collaborate with national and international partners to create and promote data sharing standards, protocols and implementations.
- Head, Adaptive Oncology, OICR
- Chair of the International Cancer Genome Consortium Executive Committee, International Scientific Steering Committee and Data Coordination and Management Committee
- Member of the Pan Cancer Analysis of Whole Genomes (PCAWG) Steering Committee
- Member of the ICGCmed Scientific Planning Committee Data Coordination and Management Committee
- Professor, Department of Molecular Genomics, University of Toronto
- Shuai S, Suzuki H, Diaz-navarro A, …, Stein LD. The U1 spliceosomal RNA is recurrently mutated in multiple cancers. Nature. 2019;574(7780):712-716.
- Vladoiu MC, El-hamamy I, Donovan LK, …, Stein L, Taylor MD. Childhood cerebellar tumours mirror conserved fetal transcriptional programs. Nature. 2019;572(7767):67-73.
- Shlush LI, Zandi S, Mitchell A, …, Stein LD, …, Dick JE. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature. 2014;506(7488):328-33.
- Gonzalez-Perez A, Mustonen V, Reva B, …, Stein LD, Lopez-Bigas N; International Cancer Genome Consortium Mutation Pathways and Consequences Subgroup of the Bioinformatics Analyses Working Group. Computational approaches to identify functional genetic variants in cancer genomes. Nat Methods. 2013;10(8):723-9.
- Trinh QM, Jen FY, Zhou Z, …, Stein LD. Cloud-based uniform ChIP-Seq processing tools for modENCODE and ENCODE. BMC Genomics. 2013;14:494.
Dr. Stein was named one of the World’s Most Influential Scientific Minds by Thompson Reuters in 2014 and a Fellow of the International Society of Computational Biology (ISCB) in 2016. He was recently awarded the Canadian Cancer Research Alliance’s Outstanding Achievements in Cancer Research Award (2019).
Previous experience and education
- Interim Scientific Director, OICR
- Program Director, Informatics and Bio-computing, OICR
- Professor, Cold Spring Harbor, New York
- Associate Professor, Cold Spring Harbor, New York
- Director Information Systems, CuraGen Corporation
- Instructor, Harvard Medical School, Deptartment of Pathology, Brigham and Women’s Hospital
- Director, Informatics Core, MIT Genome Center, Whitehead Institute for Biomedical Research, MIT
- Residency, Anatomic Pathology, Brigham and Women’s Hospital
- MD, Harvard Medical School
- PhD, Cell Biology, Harvard University
Dr. Lincoln Stein