Dr. Trevor Pugh

Senior Investigator & Director, Genomics

Trevor PughDr. Trevor Pugh is a Senior Investigator and the Director of Genomics at OICR. He leads the OICR Genomics program, which brings together the Princess Margaret Genomics Centre, OICR’s Genome Technologies, Translational Genomics Laboratory and Genome Sequence Informatics teams under an integrated initiative to support basic, translational and clinical research.

Dr. Pugh is a cancer genomics researcher and a board-certified molecular geneticist. His research program is focused on understanding the clinical implications of clonal shifts in cancer and non-cancerous cell populations in tumours during treatment, most recently using cell-free DNA sequencing, single cell RNA-seq analysis, and immune repertoire profiling. He and his collaborators develop software tools and data analysis systems required to enable the aforementioned goals.

Current affiliations

  • Senior Investigator & Director, Genomics, OICR
  • Canada Research Chair in Translational Genomics
  • Associate Professor, Department of Medical Biophysics, University of Toronto
  • Senior Scientist, Princess Margaret Cancer Centre

Research interests

  • Cancer Genomics
  • Clinical Molecular Genetics
  • Bioinformatics
  • Software development

Top publications

See Dr. Pugh’s recent publications on PubMed or on Google Scholar.

Awards

  • Canadian Institutes of Health Research, Canada Research Chair in Translational Genomics, 2018
  • StandUp2Cancer, Philip A. Sharp Award for Innovation in Collaboration, 2018
  • Terry Fox Research Institute, New Investigator Award, 2017

Tools

  • Liquid Biopsy Sequencing: Ultra-deep targeted sequencing to detect somatic mutations in cell-free DNA
  • CapTCRSeq: A DNA hybrid capture method for assessment of T-cell receptor clonality (Similar bait set developed for the immunoglobulin / B-cell receptor loci)

Patents

  • Hybrid-capture sequencing for determining immune cell clonality, WO2017177308A1, 2017

Previous experience

  • Clinical Molecular Genetics Fellow (ACMG), Harvard Medical School
  • Postdoctoral Fellow, Dana-Farber Cancer Institute and the Broad Institute of Harvard and MIT
  • PhD, University of British Columbia
  • B.Sc., University of British Columbia

Opportunities to collaborate

For opportunities to collaborate with Dr. Pugh, please contact the PM-OICR Translational Genomics Laboratory.

Visit OICR’s Collaborative Research Resources directory for more opportunities to collaborate with OICR researchers.

Related links

University Health Network Researcher Page – Dr. Trevor Pugh

University of Toronto, Department of Medical Biophysics Faculty Page – Dr. Trevor Pugh

PM-OICR Translational Genomics Laboratory

Contact

Dr. Trevor Pugh
trevor.pugh@utoronto.ca