Dr. Trevor Pugh

Director, Translational Genomics Laboratory

Dr. Trevor Pugh directs the Princess Margaret-OICR Translational Genomics Laboratory (PM-OICR). He is a cancer genomics researcher and a board-certified molecular geneticist.

Dr. Pugh’s work focuses on enabling the use of genome technologies to guide care for cancer patients. His research program is focused on understanding the clinical implications of clonal shifts in cancer and non-cancerous cell populations in tumours during treatment, most recently using cell-free DNA sequencing, single cell RNA-seq analysis, and immune repertoire profiling. He and his lab develops software tools and data analysis systems required to enable the aforementioned goals

Current affiliations

  • Canada Research Chair in Translational Genomics;
  • Associate Professor, Department of Medical Biophysics, University of Toronto;
  • Scientist, Princess Margaret Cancer Centre.

Research interests

  • Cancer Genomics;
  • Clinical Molecular Genetics;
  • Bioinformatics;
  • Software development.

Top publications

Mulder DT, Mahé ER, Dowar M, Hanna Y, Delabie J, Nguyen L, Ohashi PS, Kamel-Reid S, Pugh TJ.
CapTCRSeq: A DNA hybrid capture method for assessment of T-cell receptor clonality.
Blood Advances. 2018; (accepted).

Pugh TJ, Fink JM, Lu X, Mathew S, Murata-Collins J, Willem P, Fang M, on behalf of the Cancer Genomics Consortium Plasma Cell Disorders Working Group.
Consensus recommendations for cytogenomic testing of plasma cell neoplasms for diagnosis and prognosis.
Cancer Genet. 2018; (accepted).

Yang SYC, Lheureux S, Karakasis K, Burnier JV, Bruce JP, Clouthier DL, Danesh A, Quevedo R, Dowar M, Hanna Y, Li T, Lu L, Xu W, Clarke BA, Ohashi PS, Shaw PA, Pugh TJ, Oza AM.
Landscape of genomic alterations in high-grade serous ovarian cancer from exceptional long- and short-term survivors.
Genome Med. 2018;10(1):81.

Kis O, Kaedbey R, Chow S, Danesh A, Dowar M, Li T, Li ZH, Liu J, Mansour M, Sukhai M, Zhang T, Kamel-Reid S, Trudel S, Pugh TJ.
Circulating tumour DNA sequence analysis as an alternative to bone marrow aspirates for clinical management of multiple myeloma.
Nat Commun. 2017;8:15086.

Lheureux S, Bruce J, Brunier J, Karakasis K, Shaw PA, Clarke BA, Yang SYC, Quevedo R, Li T, Dowar M, Bowering V, Pugh TJ, Oza A.
Somatic BRCA1/2 recovery as a resistance mechanism following long-term response to PARP inhibition.
J Clin Oncol. 2017;35(11):1240-1249.

See Dr. Pugh’s recent publications on PubMed or on Google Scholar.

Awards

  • Canadian Institutes of Health Research, Canada Research Chair in Translational Genomics, 2018;
  • StandUp2Cancer, Philip A. Sharp Award for Innovation in Collaboration, 2018;
  • Terry Fox Research Institute, New Investigator Award, 2017.

Tools

  • Liquid Biopsy Sequencing: Ultra-deep targeted sequencing to detect somatic mutations in cell-free DNA
  • CapTCRSeq: A DNA hybrid capture method for assessment of T-cell receptor clonality (Similar bait set developed for the immunoglobulin / B-cell receptor loci)

Patents

  • Hybrid-capture sequencing for determining immune cell clonality, WO2017177308A1, 2017.

Previous experience

  • Clinical Molecular Genetics Fellow (ACMG), Harvard Medical School;
  • Postdoctoral Fellow, Dana-Farber Cancer Institute and the Broad Institute of Harvard and MIT;
  • PhD, University of British Columbia;
  • B.Sc., University of British Columbia.

Opportunities to collaborate

For opportunities to collaborate with Dr. Pugh, please contact the PM-OICR Translational Genomics Laboratory.

Visit OICR’s Collaborative Research Resources directory for more opportunities to collaborate with OICR researchers.

Related links

University Health Network Researcher Page – Dr. Trevor Pugh

University of Toronto, Department of Medical Biophysics Faculty Page – Dr. Trevor Pugh

PM-OICR Translational Genomics Laboratory

Contact

Dr. Trevor Pugh
trevor.pugh@utoronto.ca