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Research > Researchers
Dr. Trevor Pugh
Dr. Trevor Pugh
Contact
Dr. Trevor Pugh
Senior Investigator and Director, Genomics

trevor.pugh@utoronto.ca

Senior Investigator and Director, Genomics

Dr. Trevor Pugh is a Senior Investigator and the Director of Genomics at OICR. He leads the OICR Genomics program, which brings together the Princess Margaret Genomics Centre, OICR’s Genome Research Platform, Translational Genomics Laboratory and Genome Sequence Informatics teams under an integrated initiative to support basic, translational and clinical research.

External Links

Dr. Pugh is a cancer genomics researcher and a board-certified molecular geneticist. His research program is focused on understanding the clinical implications of clonal shifts in cancer and non-cancerous cell populations in tumours during treatment, most recently using cell-free DNA sequencing, single cell RNA-seq analysis, and immune repertoire profiling. He and his collaborators develop software tools and data analysis systems required to enable collaborative, clinically-oriented genome research.

Experience & Education
  • Clinical Molecular Genetics Fellow (ACMG), Harvard Medical School
  • Postdoctoral Fellow, Dana-Farber Cancer Institute and the Broad Institute of Harvard and MIT
  • PhD, University of British Columbia
  • B.Sc., University of British Columbia
Current Affiliations
  • Senior Investigator & Director, Genomics, OICR
  • Canada Research Chair in Translational Genomics
  • Associate Professor, Department of Medical Biophysics, University of Toronto
  • Senior Scientist, Princess Margaret Cancer Centre
Select Publications

See Dr. Pugh’s recent publications on PubMed or on Google Scholar.

Research Areas
Biology Informatics and Data Standards
Disease Areas
All
Awards
  • Canadian Institutes of Health Research, Canada Research Chair in Translational Genomics, 2018
  • StandUp2Cancer, Philip A. Sharp Award for Innovation in Collaboration, 2018
  • Terry Fox Research Institute, New Investigator Award, 2017
Opportunities to Collaborate

For opportunities to collaborate with Dr. Pugh, please contact the PM-OICR Translational Genomics Laboratory.

Collaborate with us

Visit OICR’s Collaborative Research Resources directory for more opportunities to collaborate with OICR researchers.

Programs
Genomics
Provides large-scale, next generation sequencing cancer genomics capabilities to researchers in Ontario and beyond.
Learn More
Tools
  • Liquid Biopsy Sequencing: Ultra-deep targeted sequencing to detect somatic mutations in cell-free DNA
  • CapTCRSeq: A DNA hybrid capture method for assessment of T-cell receptor clonality (Similar bait set developed for the immunoglobulin / B-cell receptor loci)
Patents
  • Hybrid-capture sequencing for determining immune cell clonality, WO2017177308A1, 2017
In the News
OICR Genomics achieves CAP laboratory accreditation
OICR Genomics achieves CAP laboratory accreditation
Apr 26, 2021
 OICR-affiliated researchers awarded $6.6 million in funding from CIHR
OICR-affiliated researchers awarded $6.6 million in funding from CIHR
Mar 09, 2021
 Clinical trial breaks new ground on using immunotherapy for more cancer types
Clinical trial breaks new ground on using immunotherapy for more cancer types
Sep 07, 2021
 Third major accreditation to help OICR Genomics power next generation of precision medicine
Third major accreditation to help OICR Genomics power next generation of precision medicine
Apr 04, 2023
 OICR introduces groundbreaking test proven to find traces of cancer in blood
OICR introduces groundbreaking test proven to find traces of cancer in blood
Jul 25, 2023
 The secret to stopping deadly cancer recurrences may be in your blood
The secret to stopping deadly cancer recurrences may be in your blood
Aug 11, 2023
 Landmark study uses OICR Genomics test to find early signs of cancer in blood
Landmark study uses OICR Genomics test to find early signs of cancer in blood
Oct 24, 2023
 Blood test detects tumours early in families with cancer
Blood test detects tumours early in families with cancer
Oct 24, 2023
 Using AI to connect cancer patients with cutting-edge clinical trials
Using AI to connect cancer patients with cutting-edge clinical trials
Feb 27, 2024
 Ask a cancer researcher: Is there a blood test for cancer?
Ask a cancer researcher: Is there a blood test for cancer?
Mar 22, 2024
 No tumour sample, no problem: Blood test predicts immunotherapy outcomes without biopsy
No tumour sample, no problem: Blood test predicts immunotherapy outcomes without biopsy
Jul 23, 2024
 OICR researchers inducted into Royal Society of Canada
OICR researchers inducted into Royal Society of Canada
Nov 11, 2024
 ‘Ultrarapid’ genomic testing could shift paradigm for cancer treatment
‘Ultrarapid’ genomic testing could shift paradigm for cancer treatment
Mar 26, 2025